{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:06:22Z","timestamp":1777579582530,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report a case of bilateral nonarteritic anterior ischemic optic neuropathy (NAION) in a hepatitis C (HCV) infected patient and demonstrate the relationship between HCV and the development of NAION.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 43-year-old woman with chronic HCV infection and long-term euthyroid autoimmune thyroiditis suddenly lost vision in her right eye, and 6 months later in her left eye, due to NAION. Slightly elevated levels of aminotransferases suggested liver infection activity. Anti-HCV antibody was detected; the genotype of the virus was 1b and the viral RNA level was 1.8 \u00d7 106 IU\/mL. Liver biopsy proved chronic active hepatitis (Ishak score grading: 7, staging: 2). Except for the elevated levels of antithyroid antibodies and a weak antinuclear factor, the detailed laboratory examinations (thrombophilia, cryoglobulin, anticardiolipin antibodies, co-infections) revealed no other abnormalities; a causative relationship between the underlying chronic hepatitis C and bilateral NAION therefore seems probable. The patient was treated with pegylated interferon and ribavirin for 1 year and a sustained viral remission could be achieved. Her vision has neither improved nor deteriorated further.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This appears to be the first reported case of bilateral NAION presumably caused by HCV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210801800226","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:48:34Z","timestamp":1516322914000},"page":"313-315","source":"Crossref","is-referenced-by-count":12,"title":["Hepatitis C Virus Presumably Associated Bilateral Consecutive Anterior Ischemic Optic Neuropathy"],"prefix":"10.1177","volume":"18","author":[{"given":"M.","family":"Fodor","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Debrecen, Debrecen - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Debrecen, Debrecen - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Berta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Debrecen, Debrecen - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Tornai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Debrecen, Debrecen - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pfliegler","sequence":"additional","affiliation":[{"name":"Division of Rare Diseases, Medical and Health Sciences Center, Faculty of Medicine, University of Debrecen, Debrecen - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-112067210801800226","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200312000-00003"},{"key":"bibr2-112067210801800226","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31291-7"},{"key":"bibr3-112067210801800226","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01741-4"},{"key":"bibr4-112067210801800226","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1997.tb00692.x"},{"key":"bibr5-112067210801800226","doi-asserted-by":"publisher","DOI":"10.1159\/000070195"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:53Z","timestamp":1777405073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210801800226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1177\/112067210801800226"],"URL":"https:\/\/doi.org\/10.1177\/112067210801800226","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}