{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:06:58Z","timestamp":1777579618588,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the 12-hour efficacy and safety of dorzolamide\/timolol fixed combination (DTFC) dosed twice daily versus latanoprost dosed every evening following a timolol run-in in primary open-angle glaucoma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following a 6-week timolol run-in patients were randomized to either DTFC or latanoprost for 6 weeks and then changed to the opposite treatment for 6 weeks. At the end of the run-in, and the end of each treatment period, the intraocular pressure (IOP) was measured every 2 hours between 8:00 AM and 8:00 PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-one patients completed at least one time point in both treatment periods. Both treatments reduced the IOP for the diurnal curve, and at each time point, from the timolol run-in baseline (p&lt;0.0001). The 12-hour IOP on timolol was 22.1\u00b12.8 mmHg, whereas on DTFC it was 18.1\u00b12.8 and latanoprost 18.3\u00b13.1 mmHg (p=0.4). Further, there was no statistical difference in IOP between treatments at any time point (p\u22640.1). There was no statistical difference for any individual adverse event between treatments (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that following a timolol run-in both DTFC and latanoprost provide comparable daytime efficacy and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210801800409","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:45:20Z","timestamp":1516322720000},"page":"556-562","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Daytime Efficacy and Safety of Dorzolamide\/Timolol Maleate Fixed Combination versus Latanoprost"],"prefix":"10.1177","volume":"18","author":[{"given":"J.","family":"Mulaney","sequence":"first","affiliation":[{"name":"Central Florida Eye Associates, Lakeland, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sonty","sequence":"additional","affiliation":[{"name":"Midwest Eye Center, Calumet City, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Midwest Eye Center, Calumet City, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.C.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Dallas, TX"},{"name":"Carolina Eye Institute, University of South Carolina, School of Medicine, Columbia, SC - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800206"},{"key":"bibr2-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30798-1"},{"key":"bibr3-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30749-5"},{"key":"bibr4-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30750-1"},{"key":"bibr5-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1999.770214.x"},{"key":"bibr6-112067210801800409","first-page":"17","volume":"106","author":"Clineschmidt C.M.","year":"1999","journal-title":"Ophthalmology"},{"key":"bibr7-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.11.1249"},{"key":"bibr8-112067210801800409","first-page":"S10","volume":"106","author":"Boyle J.E.","year":"1999","journal-title":"Ophthalmology"},{"key":"bibr9-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0420.2004.0205.x"},{"key":"bibr10-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00404-4"},{"key":"bibr11-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.4.453"},{"key":"bibr12-112067210801800409","first-page":"222","volume":"7","author":"Book S.A.","year":"1978","journal-title":"New York: McGraw Hill"},{"key":"bibr13-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1998.14.129"},{"key":"bibr14-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb07052.x"},{"key":"bibr15-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199812000-00008"},{"key":"bibr16-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00381-0"},{"key":"bibr17-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1358\/dof.1992.017.08.187766"},{"key":"bibr18-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(89)90011-0"},{"key":"bibr19-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(89)90049-3"},{"key":"bibr20-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90117-1"},{"key":"bibr21-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31484-3"},{"key":"bibr22-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00902-8"},{"key":"bibr23-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2004.20.470"},{"key":"bibr24-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.08.022"},{"key":"bibr25-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01177-1"},{"key":"bibr26-112067210801800409","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00098-9"},{"key":"bibr27-112067210801800409","unstructured":"StewartW.C. 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