{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:02:55Z","timestamp":1783483375239,"version":"3.55.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Bilateral herpetic keratitis is a rare infection of the cornea. Ocular herpes in atopic patients is more often bilateral, with more frequent recurrences. The authors report a case of bilateral herpes simplex virus (HSV) keratitis during the active phase studied by in vivo confocal microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 28-year-old man with 5 years history of unilateral HSV keratitis and atopic dermatitis was referred to the authors for a clinical and diagnostic evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The corneas showed the typical features of dendritic HSV keratitis in both eyes. Examination by in vivo confocal microscopy demonstrated similar lesions in both eyes: a distortion of the superficial and basal epithelium and the presence of irregular hyperreflective structures and dendritic particles near the epithelial cells. The subbasal nerve plexus presented a tortuous appearance with hyperreflective areas and beadlike formations along the fibers. After a week of antiviral treatment, in vivo confocal microscopy examination demonstrated an irregular epithelium with highly reflective deposits and reflective areas. A reduction of nerve fiber bundles with a large number of beadlike formations and abnormal tortuosity was also noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In vivo confocal microscopy enables a noninvasive evaluation of the ocular surface at a high magnification level. It could be useful for the early and differential diagnosis of corneal infections and when HSV keratitis recurrence is suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210801800622","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:50:51Z","timestamp":1516323051000},"page":"994-997","source":"Crossref","is-referenced-by-count":23,"title":["In Vivo Confocal Microscopy in Bilateral Herpetic Keratitis: A Case Report"],"prefix":"10.1177","volume":"18","author":[{"given":"G.","family":"Martone","sequence":"first","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alegente","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Balestrazzi","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nuti","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Traversi","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pichierri","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Tosi","sequence":"additional","affiliation":[{"name":"Ophthalmology and Neurosurgery Department, University of Siena, Siena - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-112067210801800622","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.65.6.385"},{"key":"bibr2-112067210801800622","doi-asserted-by":"publisher","DOI":"10.3109\/02713689109020363"},{"key":"bibr3-112067210801800622","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200204000-00006"},{"key":"bibr4-112067210801800622","doi-asserted-by":"publisher","DOI":"10.1086\/367991"},{"key":"bibr5-112067210801800622","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/bjo.79.5.473","volume":"79","author":"Thiel M.A.","year":"1995","journal-title":"Br J Ophthalmol"},{"key":"bibr6-112067210801800622","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.06.057"},{"key":"bibr7-112067210801800622","doi-asserted-by":"publisher","DOI":"10.3109\/02713688609025172"},{"key":"bibr8-112067210801800622","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0251"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:22Z","timestamp":1777405102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210801800622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1177\/112067210801800622"],"URL":"https:\/\/doi.org\/10.1177\/112067210801800622","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}