{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:34:30Z","timestamp":1790890470339,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to document the prevalence of anisometropia, anisoastigmatism, and anisometropic amblyopia in patients with neurofibromatosis-1 (NF1) and to compare it with that in age- and sex-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty patients with NF1 and 150 age- and sex-matched controls were examined in this study. Cycloplegic autorefraction was attempted on all patients &lt;16 years old and without cycloplegia on patients &gt;16 years old. Anisometropia was defined as absolute interocular difference of spherical equivalent more than or equal to 1 D. Aniso-astigmatism was defined as interocular difference of refractive astigmatism of more than or equal to 1 D. Amblyopia was defined as two-line decrease in Snellen acuity between the two eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall prevalence of anisometropia, aniso-astigmatism, and amblyopia in patients with NF1 was 16%, 20%, and 10%, respectively, and they were all significantly higher than in the controls. The amblyopia was either moderate or severe in nature and all affected patients had significant astigmatism (&gt;2.5 D) in the amblyopic eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NF1 is a risk factor for anisometropia, aniso-astigmatism, and aniso-astigmatic amblyopia and screening patients with NF1 for refractive errors before age 3 will help to detect patients at risk of amblyopia and give them proper treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900324","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:52:55Z","timestamp":1516323175000},"page":"470-474","source":"Crossref","is-referenced-by-count":10,"title":["The prevalence of anisometropia aniso-astigmatism and amblyopia in neurofibromatosis type 1"],"prefix":"10.1177","volume":"19","author":[{"given":"Aylin","family":"Ardagil","sequence":"first","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil A.","family":"Yaylali","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan H.","family":"Erbil","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Olgun","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeki I.","family":"Aslan","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Dolar","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Research and Training Hospital, Department of Ophthalmology, Istanbul - 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