{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:11:08Z","timestamp":1777579868398,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate in a long-term period the effectiveness and safety of topographically guided two-step laser in situ keratomileusis (LASIK) and standard LASIK technique in the correction of refractive errors after successful penetrating keratoplasty (PKP) for keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>At least 2 years after PKP and 6 months after removal of all sutures, 15 eyes of 15 patients (Group 1; mean manifest refraction spherical equivalent (MRSE) \u22127.23 D \u00b1 3.42 SD) were submitted to standard LASIK and 15 eyes of 15 patients (Group 2; mean MRSE \u22124.37 D \u00b1 1.97 SD) to a topographically guided two-step LASIK procedure (first the flap and at least 2 weeks later the laser ablation). In all cases, a superior hinged corneal flap (160 \u03bcm\/9.5 mm) was created.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a follow-up of 36 months, in Group 1 the mean uncorrected visual acuity (UCVA) was 0.51 logarithm of the minimum angle of resolution (logMAR) \u00b1 0.41 SD and the mean best-corrected visual acuity (BCVA) was 0.03 logMAR \u00b1 0.05 SD, with a mean MRSE of \u22121.57 D \u00b1 2.65 SD. In Group 2, the mean UCVA was 0.28 logMAR \u00b1 0.24 SD and the mean BCVA was 0.01 logMAR \u00b1 0.03 SD, with a mean MRSE of \u22120.07 D \u00b1 1.00 SD. In both groups, no complications were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After a long follow-up period, both topographically guided two-step LASIK and standard LASIK could be considered effective and safe tools in the correction of refractive errors after successful PKP for keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900404","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:10:31Z","timestamp":1516792231000},"page":"535-543","source":"Crossref","is-referenced-by-count":7,"title":["Topographically Guided Two-Step LASIK and Standard LASIK in the Correction of Refractive Errors after Penetrating Keratoplasty"],"prefix":"10.1177","volume":"19","author":[{"given":"Leopoldo","family":"Spadea","sequence":"first","affiliation":[{"name":"Eye Clinic, San Salvatore Hospital, University 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