{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:11:16Z","timestamp":1777579876827,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the control of diurnal intraocular pressure (IOP) and the safety profile of bimatoprost in pseudoexfoliative glaucoma (PXG) compared to primary open angle glaucoma (POAG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, observer-masked, nonrandomized study was performed. Seventy consecutive patients with either POAG (35 eyes) or PXG (35 eyes) drug-naive for glaucoma were assigned to receive bimatoprost 0.03% once daily for 12 weeks. Diurnal IOP was measured at baseline and after 12 weeks at three time points (8 AM, noon, and 4 PM). Main outcomes were diurnal IOP control and achievement of target IOP (CIGTS criteria). Mean diurnal IOP, hour-by-hour IOP measurements, and safety, including serious adverse events, were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant IOP reduction from baseline was found in both groups (p&lt;0.001). Mean and hour-by-hour IOP differences between groups were not statistically significant (NS). The observed IOP values and percentages of IOP reduction were 17.0 mmHg (31.5%) and 16.4 mmHg (31.9%) in PXG and POAG eyes, respectively; the differences were not statistically significant. Six eyes (1 POAG and 5 PXG, respectively) responded with a &lt;20% IOP reduction (NS). Twenty-seven POAG (77.1%) and 23 PXG (65.7%) eyes achieved target IOP. Consequently, 20 eyes (8 POAG and 12 PXG, respectively) were classified as unable to achieve the IOP target values (NS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bimatoprost was effective and safe in lowering IOP both in open angle and pseudoexfoliative glaucoma, achieving target pressure in most patients. However, long-term efficacy in PXG must be evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900412","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:10:31Z","timestamp":1516792231000},"page":"594-600","source":"Crossref","is-referenced-by-count":0,"title":["A 12-week Study Evaluating the Efficacy of Bimatoprost 0.03% in Patients with Pseudoexfoliative and Open-Angle Glaucoma"],"prefix":"10.1177","volume":"19","author":[{"given":"Marco","family":"Ciancaglini","sequence":"first","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Carpineto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Agnifili","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Nubile","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Mastropasqua","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Science, Ophthalmic Clinic, University of Chieti, Pescara - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"bibr1-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080240092038"},{"key":"bibr2-112067210901900412","first-page":"845","volume":"92","author":"Ritch R.","year":"1994","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr3-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33664-9"},{"key":"bibr4-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090050100038"},{"key":"bibr5-112067210901900412","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1755-3768.1988.tb02628.x","volume":"184","author":"Sampaolesi R.","year":"1988","journal-title":"Acta Ophthalmol Suppl"},{"key":"bibr6-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1995.tb00273.x"},{"key":"bibr7-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1985.tb01556.x"},{"key":"bibr8-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150184006"},{"key":"bibr9-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31484-3"},{"key":"bibr10-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90115-X"},{"key":"bibr11-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01177-1"},{"key":"bibr12-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1286"},{"key":"bibr13-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01827-5"},{"key":"bibr14-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.1.57"},{"key":"bibr15-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.07.064"},{"key":"bibr16-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.106690"},{"key":"bibr17-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90147-1"},{"key":"bibr18-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00873-9"},{"key":"bibr19-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702243"},{"key":"bibr20-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1991.tb04841.x"},{"key":"bibr21-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00019-1"},{"key":"bibr22-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00212-0"},{"key":"bibr23-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00098-9"},{"key":"bibr24-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.12.015"},{"key":"bibr25-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200004000-00002"},{"key":"bibr26-112067210901900412","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70908-0"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:49Z","timestamp":1777405129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210901900412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1177\/112067210901900412"],"URL":"https:\/\/doi.org\/10.1177\/112067210901900412","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}