{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:11:36Z","timestamp":1777579896247,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Brimonidine is a third-generation selective alpha-2 adrenergic agonist that lowers intraocular pressure by decreasing aqueous humor production and increasing uveoscleral flow. Its safety profile for children &lt;2 years of age remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe a case of ingestion of a single drop of brimonidine 0.2% in a newborn, resulting in sedation, cardiorespiratory depression, and hyperglycemia within minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report adds to the existing evidence that brimonidine can have serious adverse side effects and should therefore be used with extreme caution in infants &lt;2 years of age. Additionally, safety procedures like double-checking should also include vitamins or oral supplements to improve medication safety in the neonatal intensive care unit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900429","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:10:31Z","timestamp":1516792231000},"page":"694-695","source":"Crossref","is-referenced-by-count":5,"title":["Cardiorespiratory Depression and Hyperglycemia after Unintentional Ingestion of Brimonidine in a Neonate"],"prefix":"10.1177","volume":"19","author":[{"given":"Sophie","family":"Vanhaesebrouck","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Division Woman and Child, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Cossey","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Division Woman and Child, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Cosaert","sequence":"additional","affiliation":[{"name":"Pharmacy, University Hospitals-Campus Gasthuisberg, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Allegaert","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Division Woman and Child, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Naulaers","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Division Woman and Child, Leuven - Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"bibr1-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111319"},{"key":"bibr2-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700520"},{"key":"bibr3-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2006.00734.x"},{"key":"bibr4-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(02)42013-7"},{"key":"bibr5-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3414-1"},{"key":"bibr6-112067210901900429","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)82028-5"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:52Z","timestamp":1777405132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210901900429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1177\/112067210901900429"],"URL":"https:\/\/doi.org\/10.1177\/112067210901900429","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}