{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:29:16Z","timestamp":1783740556608,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To measure the impact of the Xal-Ease\u00ae delivery device on ease of eyedrop administration and on treatment compliance and satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter, randomized, comparative, crossover study was conducted at 43 sites in France. Eligible subjects were &gt;18 years of age, were diagnosed with primary open-angle glaucoma or ocular hypertension, had been treated with latanoprost or fixed-combination latanoprost\/timolol for \u22653 months prior to enrollment, and did not require a therapy change. Subjects used either Xal-Ease or the dropper bottle for 4 weeks and then switched to the alternate delivery method for the next 4 weeks. Subjects completed questionnaires after 1 and 4 weeks in each treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 211 subjects were enrolled, 107 to the Xal-Ease\/dropper bottle group and 104 to the dropper bottle\/Xal-Ease group. Baseline demographic and ocular characteristics were similar. Use of Xal-Ease made it significantly less likely that the subject would need someone to help with drop instillation (6.9% vs 18.1%, respectively; p&lt;0.001) and reduced the problem of the tip of the bottle touching the eye (3.2% vs 35.6%, respectively; p&lt;0.001). Reported compliance rates were very high and similar across groups during both treatment periods. After 1 month of use during both treatment periods, more than 70% of subjects reported global satisfaction with Xal-Ease to their physicians. No adverse events associated with the use of Xal-Ease were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Xal-Ease generally makes administration of latanoprost or fixed-combination latanoprost\/timolol easier compared with the dropper bottle.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900609","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:16:42Z","timestamp":1520918202000},"page":"949-956","source":"Crossref","is-referenced-by-count":27,"title":["Xal-Ease\u00ae: impact of an ocular hypotensive delivery device on ease of eyedrop administration, patient compliance, and satisfaction"],"prefix":"10.1177","volume":"19","author":[{"given":"Jean-Philippe","family":"Nordmann","sequence":"first","affiliation":[{"name":"H\u00f4pital des Quinze-Vingts, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[{"name":"H\u00f4pital des Quinze-Vingts, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bron","sequence":"additional","affiliation":[{"name":"Service d'Ophtalmologie, H\u00f4pital G\u00e9n\u00e9ral, Dijon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Denis","sequence":"additional","affiliation":[{"name":"Service d'Ophtalmologie, H\u00f4pital Edouard Herriot, Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Rouland","sequence":"additional","affiliation":[{"name":"Service d'Ophtalmologie, Centre Hospitalier R\u00e9gional et Universitaire, H\u00f4pital Claude Huriez, Lille"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sellem","sequence":"additional","affiliation":[{"name":"Centre Ophtalmologique Kl\u00e9ber, Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Renard","sequence":"additional","affiliation":[{"name":"Service d'Ophtalmologie, H\u00f4pital du Val de Gr\u00e2ce, Paris - France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"bibr1-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(06)73824-4"},{"key":"bibr2-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr3-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"bibr4-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.1.48"},{"key":"bibr5-112067210901900609","first-page":"1","volume-title":"Compliance with therapeutic regimens.","author":"Sackett D.L.","year":"1976"},{"key":"bibr6-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"bibr7-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.12.035"},{"key":"bibr8-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200310000-00001"},{"key":"bibr9-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000156139.05323.26"},{"key":"bibr10-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.12.009"},{"key":"bibr11-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.103093"},{"key":"bibr12-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.11.001"},{"key":"bibr13-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.036"},{"key":"bibr14-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34796-X"},{"key":"bibr15-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.034"},{"key":"bibr16-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/j.optm.2006.06.016"},{"key":"bibr17-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(05)80028-6"},{"key":"bibr18-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000126978.03828.9e"},{"key":"bibr19-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390190143023"},{"key":"bibr20-112067210901900609","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390190043003"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210901900609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:39:02Z","timestamp":1777405142000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210901900609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1177\/112067210901900609"],"URL":"https:\/\/doi.org\/10.1177\/112067210901900609","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}