{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:12:31Z","timestamp":1777579951149,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the serum level of mediators and their relation with posterior ocular involvement in patients with Beh\u00e7et disease (BD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a prospective, institutional clinical trial including 43 patients with ocular BD. Patients were divided into two subgroups: those with active posterior segment involvement (Group A) and those with inactive ocular BD (Group B). Group A included patients with posterior uveitis (vitritis or chorioretinal involvement), while Group B included patients with no active intraocular inflammation within the last 3 months. Serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-\u03b1), vascular endothelial growth factor (VEGF), and malondialdehyde (MDA) were measured by sandwich enzyme-linked immunosorbent assay and spectrophotometric assay and compared among the groups by independent sample t test and Mann-Whitney U-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum levels of the mediators in Group A (IL-6 [23.1 pg\/mL], IL-8 [161.1 pg\/mL], TNF-\u03b1 [30.5 pg\/mL], VEGF [455.9 pg\/mL], MDA [10.7 \u03bcm]) were found to be significantly higher than those in Group B (IL-6 [12.2 pg\/mL], IL-8 [48.4 pg\/mL], TNF-\u03b1 [18.6 pg\/mL], VEGF [138.0 pg\/mL], MDA [5.1 \u03bcm]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that increased serum levels of inflammatory mediators including IL-6, IL-8, TNF-\u03b1, VEGF, and MDA were possibly involved in the development of posterior uveitis in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210901900616","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:16:42Z","timestamp":1520918202000},"page":"998-1003","source":"Crossref","is-referenced-by-count":30,"title":["Inflammatory mediators and posterior segment involvement in ocular Beh\u00e7et disease"],"prefix":"10.1177","volume":"19","author":[{"given":"Yasemin","family":"Ozdamar","sequence":"first","affiliation":[{"name":"Department of Retinal and Uveal Diseases, Ankara Ulucanlar Eye Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilufer","family":"Berker","sequence":"additional","affiliation":[{"name":"Department of Retinal and Uveal Diseases, Ankara Ulucanlar Eye Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gul","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ankara Diskapi Education and Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Soykan","sequence":"additional","affiliation":[{"name":"Department of Retinal and Uveal Diseases, Ankara Ulucanlar Eye Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Bicer","sequence":"additional","affiliation":[{"name":"Department of Retinal and Uveal Diseases, Ankara Ulucanlar Eye Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyhan Sonar","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Retinal and Uveal Diseases, Ankara Ulucanlar Eye Research Hospital, Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jale","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Hacettepe University Faculty of Medicine, Ankara - 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