{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:51:21Z","timestamp":1777578681395,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To determine the incidence of progression of primary open-angle glaucoma at individual levels of mean intraocular pressure (IOP) in patients in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A retrospective, multicenter, cohort analysis of patient records with at least 5 years of potential follow-up were evaluated for risk factors associated with progressive optic disc and visual field loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>There were 300 patients with the potential of 5 years of follow-up. In total, 166 patients progressed before 5 years and 134 remained stable for the full 5-year follow-up period. Of the total sample, 84% of patients with IOPs \u226419 (n=117\/139), 53% of patients with IOPs of 20 (n=9\/17), 14% of patients with IOPs of 21\u201324 (n=9\/63), and 0% of the patients with IOPs of \u226525 mmHg (n=0\/79) remained stable over at least 5 years. The mean IOP was 17.4\u00b12.1 in the stable group and 25.0\u00b15.9 mmHg in the progressed group (p&lt;0.0001). The highest average peak IOP was 24.5\u00b14.5 in the stable group and 29.0\u00b16.1 mmHg in the progressed group (p&lt;0.0001). A multivariant regression analysis to determine risk factors for progression was positive for mean IOP (p=0.0097).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>This study suggests that IOP reduction in a developing country, despite potential limitations in diagnostic techniques, follow-up, and compliance, can be effective in reducing the risk of glaucomatous progression over long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067211002000209","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:06:10Z","timestamp":1516791970000},"page":"310-315","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Benefit of Reduced Intraocular Pressure in Primary Open-Angle Glaucoma Patients in Ethiopia"],"prefix":"10.1177","volume":"20","author":[{"given":"Abiye M.","family":"Alemu","sequence":"first","affiliation":[{"name":"Ras Desta Hospital, Addis Ababa - Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J.","family":"Kristoffersen","sequence":"additional","affiliation":[{"name":"Charleston Research Company, LLC, Charleston, SC - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Kristoffersen","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Dallas, TX - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Dallas, TX - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Dallas, TX - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"bibr1-112067211002000209","first-page":"163","volume":"33","author":"Alemayehu W.","year":"1995","journal-title":"Ethiop Med J"},{"key":"bibr2-112067211002000209","doi-asserted-by":"publisher","DOI":"10.3109\/09286589709058057"},{"key":"bibr3-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.6.677"},{"key":"bibr4-112067211002000209","first-page":"278","volume":"76","author":"Bedri A.","year":"1999","journal-title":"East Afr Med J"},{"key":"bibr5-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1395-3907.2004.00263.x"},{"key":"bibr6-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1989.tb00754.x"},{"key":"bibr7-112067211002000209","first-page":"1729","volume":"8","author":"Alemu A.M.","year":"2008","journal-title":"Int J Ophthalmol"},{"key":"bibr8-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.532"},{"key":"bibr9-112067211002000209","first-page":"133","volume":"35","author":"Shiose Y.","year":"1991","journal-title":"Jpn J Ophthalmol"},{"key":"bibr10-112067211002000209","first-page":"1286","volume":"34","author":"Choe Y.J.","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr11-112067211002000209","first-page":"25","volume":"46","author":"Sihota R.","year":"1998","journal-title":"Indian J Ophthalmol"},{"key":"bibr12-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.007"},{"key":"bibr13-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr14-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800517"},{"key":"bibr15-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.07.060"},{"key":"bibr16-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76896-5"},{"key":"bibr17-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71282-6"},{"key":"bibr18-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00487-6"},{"key":"bibr19-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2006.22.26"},{"key":"bibr20-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"},{"key":"bibr21-112067211002000209","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702995"},{"key":"bibr22-112067211002000209","unstructured":"RitchR., ShieldsM.B., KrupinT. 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