{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:52:36Z","timestamp":1777578756999,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To report fundus auto fluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) findings in a patient with early hydroxychloroquine maculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A 50-year-old man presented with complaints of ring-like shadows in front of his eyes. He had been on hydroxychloroquine (Plaquenil) 400 mg orally twice daily for 10 years (5.14 mg\/kg\/day). Fundus examination revealed granular hypopigmentation in an arcuate pattern in the inferior parafoveal area bilaterally. The patient underwent further evaluation with SD-OCT and FAF imaging. Functional changes were assessed by microperimetry<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Hypopigmented lesions on the fundus were autofluorescent and SD-OCT corresponding to this area revealed loss of inner segment-outer segment, suggesting loss of photoreceptor layer in the affected area with underling dysfunctional retinal pigment epithelium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Findings on SD-OCT and FAF imaging support the histopathologic findings described in cases of hydroxychloroquine maculopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067211002000423","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:05:53Z","timestamp":1516791953000},"page":"785-788","source":"Crossref","is-referenced-by-count":7,"title":["Fundus Autofluorescence and Spectral Domain Optical Coherence Tomography in Early Detection of Plaquenil Maculopathy"],"prefix":"10.1177","volume":"20","author":[{"given":"Amy T.","family":"Kelmenson","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram S.","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi K.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakarla V.","family":"Chalam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"bibr1-112067211002000423","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068676"},{"key":"bibr2-112067211002000423","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01168-5"},{"key":"bibr3-112067211002000423","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.046"},{"key":"bibr4-112067211002000423","first-page":"1159","volume":"17","author":"Rosenthal R.A.","year":"1978","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr5-112067211002000423","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.6.775"},{"key":"bibr6-112067211002000423","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318164a907"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067211002000423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067211002000423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:35:28Z","timestamp":1777404928000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067211002000423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1177\/112067211002000423"],"URL":"https:\/\/doi.org\/10.1177\/112067211002000423","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}