{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:49:42Z","timestamp":1782168582269,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been \u22652 weeks with \u226519 patients per treatment arm for a crossover, and \u226550 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p\u22640.009). When 2 studies, in which timolol was used adjunctively were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p\u22640.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067211002000602","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:03:13Z","timestamp":1516791793000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":17,"title":["Meta-analysis of Timolol on Diurnal and Nighttime Intraocular Pressure and Blood Pressure"],"prefix":"10.1177","volume":"20","author":[{"given":"Princeton Wen-Yuan","family":"Lee","sequence":"first","affiliation":[{"name":"Royal Victoria Eye and Ear Hospital, Dublin - Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Doyle","sequence":"additional","affiliation":[{"name":"Royal Victoria Eye and Ear Hospital, Dublin - Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Charleston, SC - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Kristoffersen","sequence":"additional","affiliation":[{"name":"Charleston Research Company, LLC, Charleston, SC - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Stewart","sequence":"additional","affiliation":[{"name":"PRN Pharmaceutical Research Network, LLC, Charleston, SC - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"bibr1-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.004"},{"key":"bibr2-112067211002000602","unstructured":"StewartW.C. Clinical Practice of Glaucoma. Thorofare: SLACK Inc.; 1990: 255\u201397."},{"key":"bibr3-112067211002000602","unstructured":"RitchR. The Glaucomas. St. Louis: Mosby-Year Book, Inc.; 1996: 1426\u201330."},{"key":"bibr4-112067211002000602","first-page":"1315","volume":"26","author":"Topper J.E.","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr5-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.04.022"},{"key":"bibr6-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00160-9"},{"key":"bibr7-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70172-2"},{"key":"bibr8-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.10.864"},{"key":"bibr9-112067211002000602","first-page":"109","volume":"99","author":"Muzyka M.","year":"1997","journal-title":"Klin Oczna"},{"key":"bibr10-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700436"},{"key":"bibr11-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001959"},{"key":"bibr12-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.300"},{"key":"bibr13-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00131-0"},{"key":"bibr14-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.11.1553"},{"key":"bibr15-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160145002"},{"key":"bibr16-112067211002000602","first-page":"2566","volume":"41","author":"Orzalesi N.","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr17-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1253"},{"key":"bibr18-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00073-2"},{"key":"bibr19-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.898"},{"key":"bibr20-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1159\/000097903"},{"key":"bibr21-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802243366"},{"key":"bibr22-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0704-4"},{"key":"bibr23-112067211002000602","doi-asserted-by":"publisher","DOI":"10.4135\/9781412984980"},{"key":"bibr24-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1033"},{"key":"bibr25-112067211002000602","unstructured":"JMP. Statistics and Graphics Guide, Version 5. Cary, NC: SAS Institute Inc.; 2002: 251\u201364."},{"key":"bibr26-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31053-6"},{"key":"bibr27-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919280"},{"key":"bibr28-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01193-X"},{"key":"bibr29-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1080\/02713680902850075"},{"key":"bibr30-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01699-9"},{"key":"bibr31-112067211002000602","doi-asserted-by":"publisher","DOI":"10.3109\/02713689008999558"},{"key":"bibr32-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.3.221"},{"key":"bibr33-112067211002000602","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.119065"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067211002000602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067211002000602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:35:37Z","timestamp":1777404937000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067211002000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1177\/112067211002000602"],"URL":"https:\/\/doi.org\/10.1177\/112067211002000602","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}