{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:27:27Z","timestamp":1777580847740,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To quantify ocular light scattering in patients under treatment with intraocular pressure\u2013lowering eye-drops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective, observational, cross-sectional case series study, 160 eyes of 160 patients with primary open angle glaucoma or primary ocular hypertension were consecutively recruited from our Glaucoma Department over 7\u2009months. In total, 46 eyes of 46 healthy volunteers matched for age and sex served as the control group. The variables recorded in a single visit were as follows: drug and number of drops per day, treatment duration, OXFORD corneal staining grade, lower tear meniscus height as measured by spectral domain optical coherence tomography, ocular redness and non-invasive tear breakup time measured with the Oculus Keratograph 5M, ocular surface disease index questionnaire score and objective scatter index through a double-pass technique (Optical Analysis System II).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Objective scatter index was higher in the patient group (3.1, interquartile range\u2009=\u20091.8\u20135.47) than in the control group (1.95; interquartile range\u2009=\u20090.7\u20135; p\u2009=\u20090.017). In a multiple linear regression model, non-invasive tear breakup time was identified as the most influential variable on light scatter (mean ratio\u2009=\u2009\u22121.015; p\u2009=\u20090.003; 95% confidence interval\u2009=\u2009\u22121.025 to \u22121.005). No correlation with objective scatter index was observed for number of daily eye-drops, preservative concentration or treatment duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Participants on anti-glaucoma medication showed a significantly higher objective scatter index than control group individuals. In the treated patient group, a lower non-invasive tear breakup time was associated with a higher objective scatter index. This suggests that lubricating eye-drops to improve tear breakup time could also improve vision quality in these patients by diminishing light scattering.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672117753667","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T02:10:05Z","timestamp":1523326205000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraocular light scatter in patients on topical intraocular pressure\u2013lowering medication"],"prefix":"10.1177","volume":"28","author":[{"given":"Francisco","family":"P\u00e9rez-Bartolom\u00e9","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico San Carlos, Complutense University of Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Mar\u00eda","family":"Mart\u00ednez de la 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