{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:22:20Z","timestamp":1791436940187,"version":"4.3.3"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of standard corneal collagen crosslinking for children with progressive keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Prospective study including 26 eyes of 26 patients younger than 18\u2009years old with progressive keratoconus at Oftalmosalud Instituto de Ojos, Lima, Peru. Standard epi-off corneal crosslinking was performed in all eyes between January 2012 and January 2013. Pre- and postoperative evaluation (at 3\u2009years) included uncorrected and best-corrected visual acuity and Scheimpflug analysis. Crosslinking failure was defined as an increase in maximum keratometry (K\n                      <jats:sub>max<\/jats:sub>\n                      ) of more than 1\u2009diopter after 1\u2009year or more.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean uncorrected visual acuity improvement was 0.24 LogMAR (p\u2009=\u20090.07) and mean best-corrected visual acuity improvement was 0.18 LogMAR (p\u2009=\u20090.01). None of the eyes lost more than one line in the best-corrected visual acuity. Four eyes (15.38%) lost two lines in the uncorrected visual acuity at 3\u2009years postoperative. Mean steeper keratometry improvement was 1.14\u2009diopters (p\u2009=\u20090.60). Progression rate was 23.07%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Standard epi-off corneal collagen crosslinking is safe and effective to halt the progression of the keratoconus with significant improvement in the best-corrected visual acuity at 3-year follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672118760149","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T07:38:14Z","timestamp":1521704294000},"page":"415-418","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Long-term efficacy and safety after corneal collagen crosslinking in pediatric patients: Three-year follow-up"],"prefix":"10.1177","volume":"28","author":[{"given":"Maria A","family":"Henriquez","sequence":"first","affiliation":[{"name":"Research Department, Oftalmosalud Institute of Eyes, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Villegas","sequence":"additional","affiliation":[{"name":"Research Department, Oftalmosalud Institute of Eyes, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirel","family":"Rincon","sequence":"additional","affiliation":[{"name":"Research Department, Oftalmosalud Institute of Eyes, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Research Department, Oftalmosalud Institute of Eyes, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Luis","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Research Department, Oftalmosalud Institute of Eyes, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"bibr1-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.07.006"},{"key":"bibr2-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.05.029"},{"key":"bibr3-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.01.025"},{"key":"bibr4-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000233954.86723.25"},{"key":"bibr5-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.09.033"},{"key":"bibr6-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181eeaea1"},{"key":"bibr7-1120672118760149","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-01"},{"key":"bibr8-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.012"},{"key":"bibr9-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001102"},{"key":"bibr10-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/608041"},{"key":"bibr11-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000197"},{"key":"bibr12-1120672118760149","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-02"},{"key":"bibr13-1120672118760149","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20140527-03"},{"key":"bibr14-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.020"},{"key":"bibr15-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/140461"},{"key":"bibr16-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000923"},{"key":"bibr17-1120672118760149","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.03.035"}],"container-title":["European 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