{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:27:09Z","timestamp":1790458029097,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study ocular manifestations of Marfan syndrome in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective comparative cohort study on consecutive patients up to age 17\u2009years, presenting to the interdisciplinary Marfan clinic of Charit\u00e9-University Medicine Berlin over a period of 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 52 Marfan syndrome patients and 73 controls were enrolled. In Marfan syndrome eyes, the cornea was flatter (mean keratometry, 40.86\u2009\u00b1\u20092.13 vs 42.55\u2009\u00b1\u20091.55 diopters in control eyes, p\u2009&lt;\u2009.001) and corneal astigmatism was greater (1.50\u2009\u00b1\u20091.22 vs 0.88\u2009\u00b1\u20090.49 diopters in control eyes, p\u2009&lt;\u2009.001). The central cornea was thinner in Marfan syndrome eyes (537.35\u2009\u00b1\u200940.64 vs 552.95\u2009\u00b1\u200938.57\u2009\u03bcm, p\u2009=\u20090.007) and Marfan syndrome eyes were more myopic than control eyes (spherical equivalent, \u20132.77\u2009\u00b1\u20094.77 vs \u22120.64\u2009\u00b1\u20091.92 diopters, p\u2009&lt;\u2009.001). Visual acuity was reduced (logMAR 0.11\u2009\u00b1\u20090.17 vs 0.04\u2009\u00b1\u20090.26, p\u2009=\u20090.014) and intraocular pressure was lower in Marfan syndrome eyes. Iris transillumination defects were more common in Marfan syndrome eyes (19.6% vs 4.3% in control eyes, odds ratio for Marfan syndrome in the presence of iris transillumination defects\u2009=\u20097.2). Ectopia lentis was only found in Marfan syndrome eyes (25 Marfan syndrome patients, 49% with available data, bilateral in 68%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Iris transillumination defects and ectopia lentis are characteristic ocular findings in children and adolescents with Marfan syndrome. Myopia is more common and corneal curvature, central corneal thickness, and visual acuity are reduced in Marfan syndrome eyes. Children with Marfan syndrome need regular comprehensive eye examinations to identify potential complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672118761333","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T01:43:05Z","timestamp":1522201385000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Ocular manifestations of Marfan syndrome in children and adolescents"],"prefix":"10.1177","volume":"29","author":[{"given":"Daniel J","family":"Salchow","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9\u2014University Medicine Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Gehle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9\u2014University Medicine Berlin, Berlin, 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