{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:27:18Z","timestamp":1777580838169,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Myelin oligodendrocyte glycoprotein autoantibodies are associated with certain optic neuritis. Little data are known about the specificity of the initial ophthalmologic presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A monocentric retrospective study (2013\u20132017) of all patients diagnosed with myelin oligodendrocyte glycoprotein+ optic neuritis in a tertiary ophthalmologic unit was conducted. The primary objective was to define the clinical ophthalmologic description of the first episode. The secondary objective was to evaluate the evolution and final diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of nine patients were included. There was no female predominance (sex ratio f\/m\u2009=\u20090.8). At the first optic neuritis episode, the average age was 39.3\u2009years (17\u201367\u2009years, standard deviation: 18.4). Initial visual acuity was low (+1.07logMAR, standard deviation: 0.77); 5 eyes out of 15 had visual acuity +2logMAR or worse. Optic neuritis was mostly painful (8\/9) and bilateral (6\/9) but asymmetric. Optic disk swelling was reported in 9\/15 eyes and 7\/9 patients and was significantly associated with lower visual acuity in the acute phase (+1.46logMAR, standard deviation: 0.67 vs +0.5, standard deviation: 0.55; p\u2009=\u20090.03). After a mean observation period of 3.3\u2009years (0.6\u20139.4\u2009years, standard deviation: 3.4), median visual acuity was 0.05logMAR. All five patients were followed up for more than 1\u2009year (5.4\u2009years, standard deviation: 3.2) had 3\u20138 relapses (mean: 4.4, standard deviation: 2.1; annualized relapse rate: 1.2, standard deviation: 0.9). Final diagnosis was chronic relapsing idiopathic optic neuritis (n\u2009=\u20094), clinically isolated optic neuritis (n\u2009=\u20093), and neuromyelitis optica spectrum disorder aquaporin 4\u2013 (n\u2009=\u20092).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Myelin oligodendrocyte glycoprotein+ optic neuritis has an atypical clinical presentation compared with multiple sclerosis and neuromyelitis optica spectrum disorder aquaporin 4+. Its evolution is closer to neuromyelitis optica spectrum disorder aquaporin 4+, with a better visual outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672118784797","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T05:31:40Z","timestamp":1530682300000},"page":"257-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical presentation of optic neuritis with autoantibodies anti-myelin oligodendrocyte glycoprotein"],"prefix":"10.1177","volume":"29","author":[{"given":"Jean-Baptiste","family":"Ducloyer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Wiertlewski","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Lebranchu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"bibr1-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.12.004"},{"key":"bibr2-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.09.007"},{"key":"bibr3-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000040"},{"key":"bibr4-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8333-7"},{"key":"bibr5-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"bibr6-1120672118784797","volume":"13","author":"Jarius S","year":"2016","journal-title":"J Neuroinflammation"},{"key":"bibr7-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6957-4"},{"key":"bibr8-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr9-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514555785"},{"key":"bibr10-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080120057025"},{"key":"bibr11-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170847"},{"key":"bibr12-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260901"},{"key":"bibr13-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513495938"},{"key":"bibr14-1120672118784797","volume":"115","author":"Optic Neuritis Study Group","year":"2008","journal-title":"Ophthalmology"},{"key":"bibr15-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.005"},{"key":"bibr16-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00862-6"},{"key":"bibr17-1120672118784797","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0720-6"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118784797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672118784797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118784797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:43:57Z","timestamp":1777405437000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672118784797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1177\/1120672118784797"],"URL":"https:\/\/doi.org\/10.1177\/1120672118784797","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]}}}