{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:19:27Z","timestamp":1788801567486,"version":"build-2803163510"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the bactericidal activity of a diluted povidone-iodine formulation (0.6%) in comparison with the most used 5% povidone-iodine solution ophthalmic preparation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In vitro bactericidal activity comparison between 0.6% povidone-iodine versus 5% povidone-iodine formulations, against these bacteria: Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300, Staphylococcus epidermidis ATCC 12228, linezolid-resistant Staphylococcus epidermidis \u03b199 strain, a clinical isolate, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      About 0.6% povidone-iodine formulation was demonstrated to be faster than 5% povidone-iodine preparation in killing Gram-positive as well as Gram-negative bacteria. Against a linezolid-resistant methicillin-resistant Staphylococcus epidermidis strain, 0.6% povidone-iodine formulation showed the best antiseptic efficacy requirement of 3-log\n                      <jats:sub>10<\/jats:sub>\n                      reduction in bacterial load, if compared with the 5% povidone-iodine formulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our investigation has demonstrated that the more diluted 0.6% preparation was more rapidly bactericidal than the 5% povidone-iodine formulation, most probably due to the fact that dilution from 5% to 0.6% increases the amount of free iodine. While our finding must be confirmed by in vivo clinical studies, this fact constitutes an intriguing news for what concerns the use of povidone-iodine eye drops in the ocular surface treatment before intravitreal injections as well as ophthalmic surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672118802541","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T01:35:32Z","timestamp":1538962532000},"page":"673-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["In vitro bactericidal activity of 0.6% povidone-iodine eye drops formulation"],"prefix":"10.1177","volume":"29","author":[{"given":"Rosario","family":"Musumeci","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Microbiology and Virology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Virology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Calaresu","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Virology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina Elvezia","family":"Cocuzza","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Virology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,7]]},"reference":[{"key":"bibr1-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90477-0"},{"key":"bibr2-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74560-X"},{"key":"bibr3-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(85)80063-3"},{"key":"bibr4-1120672118802541","unstructured":"ESCRS guidelines on prevention and treatment of endophthalmitis after cataract surgery. The European Society of Cataract and Refractive Surgeons, 2013, http:\/\/www.escrs.org\/endophthalmitis\/guidelines\/ENGLISH.pdf (accessed 15 January 2017)."},{"key":"bibr5-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.258"},{"key":"bibr6-1120672118802541","volume-title":"Proceedings of the retina society annual meeting","author":"Heier J."},{"key":"bibr7-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.09.036"},{"key":"bibr8-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.15.4.635-639.1982"},{"key":"bibr9-1120672118802541","unstructured":"Department of Health and Human Services, US Food and Drug Administration. 21 CFR part 310. Safety and effectiveness of health care antiseptics; topical antimicrobial drug products for over-the-counter human use; proposed amendment of the tentative final monograph; reopening of administrative record. Federal Register 2015; 80(84), https:\/\/www.gpo.gov\/fdsys\/pkg\/FR-2015-05-01\/pdf\/2015-10174.pdf (accessed 18 June 2017)."},{"key":"bibr10-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01701-4"},{"key":"bibr11-1120672118802541","unstructured":"Iodine Gottardi W. and iodine compounds. In: Seymour SB (ed.) Disinfection, sterilization, and preservation. 4th ed. Philadelphia, PA: Lea & Febiger, 1991, pp. 152\u2013181."},{"key":"bibr12-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-361150-5.50011-0"},{"key":"bibr13-1120672118802541","unstructured":"BASF SE\u2014Care Chemical Division. PVP-iodine grades. Technical information, August 2010, https:\/\/industries.basf.com\/bin\/bws\/documentDownload.en.8805242644949"},{"key":"bibr14-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.2379"},{"issue":"7","key":"bibr15-1120672118802541","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.ophtha.2010.12.014","volume":"118","author":"Kim SJ","year":"2011","journal-title":"Ophthalmology"},{"key":"bibr16-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.02.024"},{"key":"bibr17-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050090092039"},{"key":"bibr18-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.07.002"},{"key":"bibr19-1120672118802541","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2017.01.007"},{"key":"bibr20-1120672118802541","first-page":"377","volume":"2","author":"Emerson MV","year":"2008","journal-title":"Clin Ophthalmol"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118802541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672118802541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118802541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:04Z","timestamp":1777405444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672118802541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,7]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/1120672118802541"],"URL":"https:\/\/doi.org\/10.1177\/1120672118802541","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,7]]}}}