{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:32:12Z","timestamp":1777581132182,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of brinzolamide\u2013brimonidine fixed combination to control the intraocular pressure elevation throughout the first 24\u2009h following uncomplicated phacoemulsification cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A total of 62 patients who underwent phacoemulsification cataract surgery were included in this prospective randomized comparative case series. The brinzolamide\u2013brimonidine fixed combination group (34 eyes) was administered a single dose of brinzolamide\u2013brimonidine fixed combination immediately after phacoemulsification. No treatment was administered in the control group (28 eyes). Intraocular pressure was measured 1\u2009day before surgery (baseline) and at 6, 12 and 24\u2009h postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The brinzolamide\u2013brimonidine fixed combination group had significantly lower intraocular pressure at 6, 12 and 24\u2009h after phacoemulsification compared to baseline (p\u2009&lt;\u20090.0001 for all comparisons), while in control group, intraocular pressure was significantly higher at 6 and 12\u2009h after surgery compared to baseline (p\u2009&lt;\u20090.001 and p\u2009&lt;\u20090.0001, respectively). In control group, an intraocular pressure elevation\u2009\u2a7e\u20095\u2009mm\u2009Hg was noted in 32.4% of the eyes at 6 and 12\u2009h and in 5.9% of eyes at 24\u2009h after surgery, while in brinzolamide\u2013brimonidine fixed combination group, only 8.8% of the eyes at 6\u2009h postoperatively had such an intraocular pressure elevation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The administration of a single drop of brinzolamide\u2013brimonidine fixed combination effectively prevented intraocular pressure elevations and intraocular pressure spikes during the first 24\u2009h after uneventful phacoemulsification.<\/jats:p>\n                  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