{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:24Z","timestamp":1777581204395,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with congenital aniridia usually have some degree of foveal hypoplasia, thus representing a limiting factor in the final visual acuity achieved by these patients. The purpose of this study was to analyze whether the foveal morphology assessed by spectral-domain optical coherence tomography may serve as a prognostic indicator for best-corrected visual acuity in congenital aniridia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Observational two-center study performed between January 2012 and March 2017 in the pediatric ophthalmology department at Vissum Alicante and Vissum Madrid, Spain. A total of 31 eyes from 19 patients with congenital aniridia were included. After a complete ophthalmological examination, a high-resolution spectral-domain optical coherence tomography with a three-dimensional scan program macular protocol was used. A morphological grading system of foveal hypoplasia was used varying from grade 1 in which there is a presence of a shallow foveal pit, extrusion of inner retinal layers, outer nuclear layer widening, and a presence of outer segment lengthening to grade 4 in which none of these processes occur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No correlation between central, mid-peripheral, and peripheral macular thickness and logMAR best-corrected visual acuity was found. The presence of outer segment lengthening was associated with better best-corrected visual acuity with a median best-corrected visual acuity, 0.30 logMAR, whereas the absence of this morphologic feature was associated with poorer VA with a median best-corrected visual acuity of 0.61 logMAR (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Foveal hypoplasia morphology can predict the best-corrected visual acuity. Specifically, the morphologic optical coherence tomography feature that is related to a better best-corrected visual acuity in congenital aniridia patients is the presence of outer segment lengthening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672118818352","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T06:37:00Z","timestamp":1545028620000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia"],"prefix":"10.1177","volume":"30","author":[{"given":"Pilar","family":"Casas-Llera","sequence":"first","affiliation":[{"name":"VISSUM Alicante, Alicante, Spain"},{"name":"VISSUM Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Siverio","sequence":"additional","affiliation":[{"name":"VISSUM Alicante, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Esquivel","sequence":"additional","affiliation":[{"name":"VISSUM Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bautista","sequence":"additional","affiliation":[{"name":"VISSUM Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L","family":"Ali\u00f3","sequence":"additional","affiliation":[{"name":"VISSUM Alicante, Alicante, Spain"},{"name":"Miguel Hern\u00e1ndez University, Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"bibr1-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(04)80028-0"},{"key":"bibr2-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01427.x"},{"key":"bibr3-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.100"},{"key":"bibr4-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01372.x"},{"key":"bibr5-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01310.x"},{"key":"bibr6-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01533.x"},{"key":"bibr7-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2011.06.011"},{"key":"bibr8-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.028"},{"key":"bibr9-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.907"},{"key":"bibr10-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13217"},{"key":"bibr11-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34247-6"},{"key":"bibr12-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1007\/BF02002774"},{"key":"bibr13-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.018"},{"key":"bibr14-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.01.005"},{"key":"bibr15-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02562.x"},{"key":"bibr16-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037638"},{"key":"bibr17-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181d786f8"},{"key":"bibr18-1120672118818352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.11.006"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118818352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672118818352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672118818352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:16Z","timestamp":1777405456000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672118818352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1120672118818352"],"URL":"https:\/\/doi.org\/10.1177\/1120672118818352","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]}}}