{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:59Z","timestamp":1787019119725,"version":"build-2736575974"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of topical Coenzyme Q10\u2009+\u2009Vitamin E (CoQ\u2009+\u2009Vit.E) molecules on retinal ganglion cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Mechanic optic nerve injury model was created in the right eyes of rats (n\u2009=\u200912). Rats were divided into two groups: glaucoma model with sham treatment and topical CoQ\u2009+\u2009Vit.E treatment. Treatment was applied for 4\u2009weeks. Glial fibrillary acidic protein, Brn-3a antibody, and anti-Iba1 were examined by immunohistochemistry. Glial fibrillary acidic protein, Bax, Bcl-xL, and Tfam protein expression were measured by Western blot analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The number of Brn-3a-positive retinal ganglion cell was 15.0\u2009\u00b1\u20091.0 (min: 14, max: 16) in sham treatment group and 22.2\u2009\u00b1\u20094.8 (min: 18, max: 29) in topical CoQ10\u2009+\u2009Vit.E treatment group. The protection of Brn-3a in CoQ10\u2009+\u2009Vit.E was statistically significant (p\u2009&lt;\u20090.05). Glial fibrillary acidic protein\u2013positive astroglial counts were recorded as 11.7\u2009\u00b1\u20092.1 (min: 10, max: 14) in sham treatment and 2.5\u2009\u00b1\u20091.5 (min: 1, max: 4) in topical CoQ10\u2009+\u2009Vit.E treatment group (p\u2009&lt;\u20090.05). Topical CoQ10\u2009+\u2009Vit.E treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. CoQ10\u2009+\u2009Vit.E treatment prevented apoptotic cell death by increasing Bcl-xL protein expression. Also, CoQ10\u2009+\u2009Vit.E preserved Tfam protein expression in the retina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study has shown that in glaucoma treatment the neuron protecting effect of topical CoQ10\u2009+\u2009Vit.E molecules can be valuable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119833271","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T04:26:57Z","timestamp":1552278417000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Neuroprotective effects of topical coenzyme Q10\u2009+\u2009vitamin E in mechanic optic nerve injury model"],"prefix":"10.1177","volume":"30","author":[{"given":"Selcan","family":"Ekicier Acar","sequence":"first","affiliation":[{"name":"Eye Clinic, Ankara Kecioren Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Sinan","family":"Sar\u0131cao\u011flu","sequence":"additional","affiliation":[{"name":"Eye Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Pathology Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Sepici Din\u00e7el","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"bibr1-1120672119833271","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.53049"},{"key":"bibr2-1120672119833271","doi-asserted-by":"crossref","unstructured":"Tielsch JM, Katz J, Singh K, et al. 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