{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:49Z","timestamp":1777581229051,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To examine the effect of a long-term nutritional supplementation on age-related macular degeneration progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective, double-blind, placebo-controlled study, 80 patients with intermediate age-related macular degeneration were randomized (2:1) to receive 1\u2009tablet\/day of a nutritional supplement containing a mixture of carotenoids, vitamins and omega-3 fatty acids or placebo. Age-related macular degeneration progression assessed by digital fundus photography (primary outcome) and best-corrected visual acuity were evaluated. Differences between arms were tested using chi-square test or Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-four patients completed the follow-up at 24\u2009months (48 in the treated arm and 26 in the placebo arm). An age-related macular degeneration progression was observed in the 2.1% of patients of the treated arm and in the 15.4% of patients in the placebo arm (p\u2009=\u20090.05, Fisher\u2019s exact test). Best-corrected visual acuity data alone were not statistically significant among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A clinically meaningful stabilization of intermediate age-related macular degeneration over a period of 2\u2009years may be obtained by treating patients with a mixture of carotenoids, vitamins and omega-3 fatty acids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119836007","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T07:27:46Z","timestamp":1552894066000},"page":"376-381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of 2-year nutritional supplementation on progression of age-related macular degeneration"],"prefix":"10.1177","volume":"30","author":[{"given":"Alberto","family":"Piatti","sequence":"first","affiliation":[{"name":"ASL TO5, Moncalieri, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Croce","sequence":"additional","affiliation":[{"name":"ASL Citt\u00e0 di Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Mazzacane","sequence":"additional","affiliation":[{"name":"ASST Pavia and Melegnano, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Traina","sequence":"additional","affiliation":[{"name":"ASL Toscana Nord Ovest, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"ASL Napoli 1 Centro, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Boni","sequence":"additional","affiliation":[{"name":"ASL Toscana Sud Est, Arezzo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lisi","sequence":"additional","affiliation":[{"name":"ASL Roma 2, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Caterina","family":"Cascella","sequence":"additional","affiliation":[{"name":"ASL di Bari, presidio F. Iaia, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Grunberger","sequence":"additional","affiliation":[{"name":"ATS Sardegna, SASSL Nuoro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"bibr1-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.035"},{"key":"bibr2-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000036"},{"key":"bibr3-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71029"},{"key":"bibr4-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02357.x"},{"key":"bibr5-1120672119836007","first-page":"CD000254","volume":"7","author":"Evans JR","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.021"},{"key":"bibr7-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"bibr8-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.005"},{"key":"bibr9-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1159\/000441359"},{"key":"bibr10-1120672119836007","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(99)00031-8"},{"key":"bibr11-1120672119836007","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000069"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119836007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119836007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119836007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:28Z","timestamp":1777405468000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119836007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/1120672119836007"],"URL":"https:\/\/doi.org\/10.1177\/1120672119836007","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]}}}