{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:49Z","timestamp":1777581229768,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report that metastatic choroidal melanoma (systemic and intraocular) can respond to systemic immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In 2010, a 64-year-old woman with a choroidal melanoma was treated with palladium-103 plaque brachytherapy. Developing 2.5\u2009years later, radiation maculopathy was suppressed with periodic intravitreal anti\u2013vascular endothelial growth factor injections for five additional years. Development of a new, discrete choroidal melanoma in the same eye prompted radiographic imaging of the orbits, abdomen\/pelvis, and chest. Multi-organ metastasis in the eye, the liver, and nodes was treated with systemic combination immunotherapy with ipilimumab (3\u2009mg\/kg) and nivolumab (1\u2009mg\/kg) intravenous every 3\u2009weeks for four cycles followed by nivolumab (3\u2009mg\/kg) intravenous every 4\u2009weeks as maintenance. Subsequent ophthalmic and systemic surveillance were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All sites of metastases were found to regress on systemic immunotherapy. For example, ophthalmic ultrasound imaging revealed that the intraocular metastasis was reduced from 6.6 to 1.5\u2009mm in thickness. Synchronously, serial radiographic imaging revealed progressive shrinkage and disappearance of hepatic and nodal metastasis (except for one gastrohepatic node). However, combination stereotactic body radiation therapy (30\u2009Gy) with nivolumab maintenance was found to induce a significant reduction in this remaining node. Continued periodic intraocular anti\u2013vascular endothelial growth factor therapy has suppressed her radiation maculopathy resulting in 20\/25 vision, now 8 \u00bd\u2009years after initial plaque therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case shows that metastatic choroidal melanoma can present in the same eye as the primary tumor. It also shows that systemic immunotherapy can control both ocular and systemic metastases as well as prolong both life and sight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119839925","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T03:31:54Z","timestamp":1554348714000},"page":"NP69-NP73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Ipsilateral metastatic choroidal melanoma responds to systemic immunotherapy"],"prefix":"10.1177","volume":"30","author":[{"given":"Moanes","family":"Morkos","sequence":"first","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Jain","sequence":"additional","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C","family":"Pavlick","sequence":"additional","affiliation":[{"name":"Perlmutter Cancer Center, School of Medicine, New York University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T","family":"Finger","sequence":"additional","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"},{"name":"Perlmutter Cancer Center, School of Medicine, New York University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"bibr1-1120672119839925","first-page":"1899","volume-title":"DeVita, Hellman, and Rosenberg\u2019s cancer: principles & practice of oncology","author":"Finger PT","year":"2019","edition":"11"},{"key":"bibr2-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.12.1639"},{"key":"bibr3-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.014"},{"key":"bibr4-1120672119839925","first-page":"805","volume-title":"AJCC cancer staging manual","author":"Kivela T","year":"2016","edition":"8"},{"key":"bibr5-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118776146"},{"key":"bibr6-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.052159"},{"key":"bibr7-1120672119839925","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000670"},{"key":"bibr8-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0671-4"},{"key":"bibr9-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.038"},{"key":"bibr10-1120672119839925","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-48-574-863"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119839925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119839925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119839925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:30Z","timestamp":1777405470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119839925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,4]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/1120672119839925"],"URL":"https:\/\/doi.org\/10.1177\/1120672119839925","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,4]]}}}