{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:49Z","timestamp":1777581229796,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare long-term results between accelerated and standard corneal cross-linking protocols in the treatment of progressive keratoconus and compare their effectiveness between central (cone in the central 3\u2009mm) and peripheral (cone beyond 3\u2009mm) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this randomized clinical trial, we compared 31 eyes treated with accelerated corneal cross-linking (18\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 5\u2009min) and 31 eyes treated with standard corneal cross-linking (3\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 30\u2009min), 16 central and 11 peripheral keratoconus in each group. In this report, 4-year changes in vision, refraction, topography, corneal biomechanics, and corneal cell count were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Uncorrected distance visual acuity improvement was better with standard corneal cross-linking (0.19\u2009\u00b1\u20090.30\u2009logMAR) than accelerated corneal cross-linking (0.08\u2009\u00b1\u20090.35\u2009logMAR), but the intergroup difference was not statistically significant (p\u2009=\u20090.283). Cylinder and spherical equivalent significantly increased similarly in both groups. Among topographic indices, anterior Kmax-3\u2009mm showed more reduction in standard corneal cross-linking than accelerated corneal cross-linking (1.35\u2009\u00b1\u20091.39 vs 0.36\u2009\u00b1\u20091.10\u2009D, p\u2009=\u20090.011). Anterior Kmax-8\u2009mm reduced by 1.50\u2009\u00b1\u20091.82 and 0.37\u2009\u00b1\u20091.58\u2009D in the standard corneal cross-linking and accelerated corneal cross-linking groups, respectively (p\u2009=\u20090.029). Compared to 18-month results, none of the indices at 4\u2009years showed any significant intergroup difference (all p\u2009&gt;\u20090.05). In cases with peripheral keratoconus, changes in anterior Kmax-3\u2009mm (+0.03\u2009\u00b1\u20090.66 vs \u22121.17\u2009\u00b1\u20091.15\u2009D, p\u2009=\u20090.012) and anterior Kmax-8\u2009mm (+0.43\u2009\u00b1\u20091.09 vs \u22121.57\u2009\u00b1\u20091.40\u2009D, p\u2009=\u20090.003) were greater with standard corneal cross-linking. In central cases, no significant intergroup difference was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>At 4\u2009years after the procedure, standard corneal cross-linking offered better anterior corneal flattening in the center and periphery. These differences concerned cases of peripheral keratoconus, and the two protocols were similarly effective in central cases. Beyond the 18th month, the two protocols appeared to be similarly effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119839927","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T03:52:48Z","timestamp":1554349968000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Standard and accelerated corneal cross-linking long-term results: A randomized clinical trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Hassan","family":"Hashemi","sequence":"first","affiliation":[{"name":"Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoomeh","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Asgari","sequence":"additional","affiliation":[{"name":"Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"bibr1-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"bibr2-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"bibr3-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302556"},{"key":"bibr4-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.012"},{"key":"bibr5-1120672119839927","first-page":"67","volume":"38","author":"Sadoughi MM","year":"2018","journal-title":"Int Ophthalmol"},{"key":"bibr6-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.05.019"},{"key":"bibr7-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.12.014"},{"key":"bibr8-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.07.030"},{"issue":"6","key":"bibr9-1120672119839927","first-page":"e1","volume":"60","author":"Hashemi H","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"bibr10-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000758"},{"key":"bibr11-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11409"},{"key":"bibr12-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7818"},{"key":"bibr13-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13748"},{"key":"bibr14-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.12.012"},{"key":"bibr15-1120672119839927","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20170621-04"},{"key":"bibr16-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1038\/srep14425"},{"key":"bibr17-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-199812000-00011"},{"key":"bibr18-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2001.00596.x"},{"key":"bibr19-1120672119839927","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20120518-02"},{"key":"bibr20-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.01.045"},{"key":"bibr21-1120672119839927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.10.052"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119839927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119839927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119839927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:30Z","timestamp":1777405470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119839927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/1120672119839927"],"URL":"https:\/\/doi.org\/10.1177\/1120672119839927","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,4]]}}}