{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:44:23Z","timestamp":1790628263076,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Management of Graves\u2019 ophthalmopathy remains challenging. Over the last decade, previous studies have shown promising results for Rituximab in the treatment of Graves\u2019 ophthalmopathy. We present the response of 14 individuals with active moderate-to-severe Graves\u2019 ophthalmopathy to Rituximab, representing one of the largest retrospective case series reported to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Rituximab was administered intravenously, 1000\u2009mg twice at a 2-week interval. The primary end point was a clinical activity score reduction (improvement by \u2a7e\u20092 points or disease inactivation: clinical activity score\u2009&lt;\u20093) at 24\u2009weeks. Secondary end points included clinical activity score improved by \u2a7e\u20092 points or inactivation of Graves\u2019 ophthalmopathy at 12\u2009weeks, improvement in each item of the clinical activity score, in proptosis, in severity disease by the total eye score and in diplopia according to the Gorman score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A limited improvement in clinical activity score was observed (median improvement at 24\u2009weeks by 1 point, p\u2009=\u20090.002, (5\/14 patients, 35.7%). Disease inactivation occurred in 50% of patients (7\/14 patients). At 12\u2009weeks, clinical activity score improved by \u2a7e\u20092 points in 2\/14 patients (14.3%) and inactivation of Graves\u2019 ophthalmopathy occurred in four patients (28.6%). Improvement in proptosis and total eye score was observed in 3\/9 patients (33%) and in 4\/14 patients (28.6%) at 24\u2009weeks, respectively. Only one patient experienced moderate adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Rituximab is a well-tolerated treatment with a good safety profile, but offered limited and partial improvement for active moderate-to-severe Graves\u2019 ophthalmopathy with a long duration of disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119845224","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T07:10:36Z","timestamp":1556262636000},"page":"1008-1013","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["The effects of Rituximab on Graves\u2019orbitopathy: A retrospective study of 14 patients"],"prefix":"10.1177","volume":"30","author":[{"given":"Laura","family":"Eid","sequence":"first","affiliation":[{"name":"Ophthalmology 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