{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:49:09Z","timestamp":1793152149775,"version":"4.5.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>To identify novel velocity waveform parameters of the ophthalmic artery and central retinal artery by computer-aided image processing of Doppler ultrasonography measurements, and to evaluate correlations between the waveform parameters and different demographics and disease severity of open-angle glaucoma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-six images of 36 open-angle glaucoma patients were considered. A semiautomated image processing code was used to detect the digitalized ophthalmic artery and central retinal artery velocity waveforms and to extract the waveform parameters. Concordance correlation coefficient, two-sample t-test, and Pearson\u2019s correlation coefficient were used to test for similarities, differences, and associations among variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Female glaucoma patients showed a statistically higher ophthalmic artery normalized distance between ascending and descending limb (p\u2009=\u20090.004), hypertensive glaucoma patients a statistically higher ophthalmic artery peak systolic velocity time (p\u2009=\u20090.025), glaucoma patients with hyperlipidemia a statistically higher ophthalmic artery resistivity index (p\u2009=\u20090.023) and a statistically higher ophthalmic artery peak systolic velocity acceleration (p\u2009=\u20090.025), glaucoma patients with cardiovascular diseases a statistically lower central retinal artery normalized distance between ascending and descending limb of the wave (p\u2009=\u20090.033) and a statistically higher central retinal artery period (p\u2009=\u20090.028), and patients with different body mass index a statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p\u2009=\u20090.016). Groups with different disease severity, classified following the Brusini glaucoma staging system 2, showed statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p\u2009&lt;\u20090.001) and central retinal artery period (p\u2009=\u20090.016). No statistical differences were found in regard to race, diabetes status, glaucoma family history, and smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Ophthalmic artery and central retinal artery computer-aided analysis of velocity waveforms could identify novel waveform parameters capable of differentiating among different demographics and disease severity of open-angle glaucoma patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119848259","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T02:13:36Z","timestamp":1557281616000},"page":"1019-1027","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity"],"prefix":"10.1177","volume":"30","author":[{"given":"Lucia","family":"Carichino","sequence":"first","affiliation":[{"name":"Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Lapin","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Washington State University, Pullman, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Guidoboni","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Cassani","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"De Silvestri","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biometric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biometric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Milano","sequence":"additional","affiliation":[{"name":"University Eye Clinic, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Siesky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C","family":"Verticchio Vercellin","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"bibr1-1120672119848259","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"bibr2-1120672119848259","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30393-5"},{"key":"bibr3-1120672119848259","unstructured":"European Glaucoma Society, terminology and guidelines for glaucoma. 4th ed. 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