{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:33:22Z","timestamp":1778862802543,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the 2-year outcomes of combination therapy using intravitreal ranibizumab and photodynamic therapy with those of fixed-dosing intravitreal aflibercept monotherapy as initial treatment for treatment-na\u00efve polypoidal choroidal vasculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed 63 eyes of 61 patients with treatment-na\u00efve polypoidal choroidal vasculopathy who had undergone at least 24 months of follow-up. In total, 43 eyes underwent intravitreal ranibizumab\u2013photodynamic therapy combination therapy and 20 eyes underwent fixed-dosing intravitreal aflibercept monotherapy. Visual outcomes and the number of treatments were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean logarithm of minimal angle of resolution best-corrected visual acuity significantly improved from 0.48 \u00b1 0.41 at baseline to 0.30 \u00b1 0.47 at 24 months in the intravitreal ranibizumab\u2013photodynamic therapy group ( p = .0002) and from 0.30 \u00b1 0.18 at baseline to 0.16 \u00b1 0.18 at 24 months in the intravitreal aflibercept group ( p = .004), with no significant intergroup differences. The mean number of intravitreal ranibizumab or intravitreal aflibercept injections over 24 months was 5.7 \u00b1 4.5 in the intravitreal ranibizumab\u2013photodynamic therapy group and 12.2 \u00b1 3.8 in the intravitreal aflibercept group ( p &lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The intravitreal ranibizumab\u2013photodynamic therapy combination therapy was noninferior to fixed-dosing intravitreal aflibercept monotherapy in improving visual acuity and required fewer injections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119871886","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T01:53:24Z","timestamp":1567475604000},"page":"1473-1479","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Initial treatment for polypoidal choroidal vasculopathy: Ranibizumab combined with photodynamic therapy or fixed-dosing aflibercept monotherapy"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-9145","authenticated-orcid":false,"given":"Ai","family":"Yoneda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan"},{"name":"Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Wakiyama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan"},{"name":"Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan"},{"name":"Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"bibr1-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199515020-00003"},{"key":"bibr2-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182852446"},{"key":"bibr3-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.11.019"},{"key":"bibr4-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13114"},{"key":"bibr5-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01404-6"},{"key":"bibr6-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-2933-2"},{"key":"bibr7-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.02.008"},{"key":"bibr8-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181f274ec"},{"key":"bibr9-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1159\/000329466"},{"key":"bibr10-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31824f91e8"},{"key":"bibr11-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.051"},{"key":"bibr12-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318225290f"},{"key":"bibr13-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.07.001"},{"key":"bibr14-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318276e096"},{"key":"bibr15-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.03.041"},{"key":"bibr16-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2323-6"},{"key":"bibr17-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2013.0044"},{"key":"bibr18-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.006"},{"key":"bibr19-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.222"},{"key":"bibr20-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1159\/000354546"},{"key":"bibr21-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305189"},{"key":"bibr22-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000526"},{"key":"bibr23-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2675-6"},{"key":"bibr24-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13130"},{"key":"bibr25-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16476-1"},{"key":"bibr26-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.4030"},{"issue":"3","key":"bibr27-1120672119871886","first-page":"413","volume":"10","author":"Zhao M","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"bibr28-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.024"},{"key":"bibr29-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000933"},{"key":"bibr30-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0305-2"},{"key":"bibr31-1120672119871886","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S129164"},{"key":"bibr32-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3489-5"},{"key":"bibr33-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001818"},{"key":"bibr34-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3718-6"},{"key":"bibr35-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1159\/000477448"},{"key":"bibr36-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.018"},{"key":"bibr37-1120672119871886","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.1804"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119871886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119871886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119871886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:50Z","timestamp":1777405490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119871886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/1120672119871886"],"URL":"https:\/\/doi.org\/10.1177\/1120672119871886","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]}}}