{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:21:58Z","timestamp":1793085718629,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to evaluate the 2-year results of epithelium-off pulsed-light accelerated corneal collagen crosslinking treatment in progressive keratoconus using 30\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ultraviolet A light for 6\u2009min with a total dose of 5.4\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 30 eyes of 22 patients with documented progressive keratoconus and treated with epithelium-off pulsed-light accelerated corneal collagen crosslinking using the KXL\u00ae crosslinking device (Avedro Inc, Waltham, MA, USA) were included in this retrospective study. Corneal tomographic measurements and best spectacle-corrected visual acuity were compared using analysis of variance with repeated measurements between the baseline visit (before the corneal collagen crosslinking treatment), and the sixth month, first, and second year visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Flat keratometry (K1), steep keratometry (K2), and mean keratometry (Km) decreased significantly at sixth month, first, and second years ( p\u2009&lt;\u20090.001, p\u2009=\u20090.001, and p\u2009&lt;\u20090.001, respectively). Maximum keratometry (Kmax) decreased from 55.40\u2009\u00b1\u20094.90\u2009D at baseline to 54.82\u2009\u00b1\u20094.68\u2009D, 54.80\u2009\u00b1\u20095.12\u2009D, and 54.65\u2009\u00b1\u20095.36\u2009D at sixth month, first year, and second year, respectively ( p\u2009=\u20090.007). The best spectacle-corrected visual acuity improved from 0.34\u2009\u00b1\u20090.24 logMAR at baseline to 0.25\u2009\u00b1\u20090.16 logMAR, 0.22\u2009\u00b1\u20090.15 logMAR, and 0.17\u2009\u00b1\u20090.13 logMAR at sixth month, first year, and second year, respectively ( p\u2009&lt;\u20090.001). At the second year visit, best spectacle-corrected visual acuity remained stable (no lines lost) with respect to the baseline in 8 eyes and increased 1 or more lines in 22 eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Pulsed-light accelerated corneal collagen crosslinking using 30\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ultraviolet A light for 6\u2009min with a total dose of 5.4\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      is an effective treatment modality in cases with progressive keratoconus\u2014it stops progression at 2\u2009years also regresses some of the cases.\n                    <\/jats:p>\n                  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