{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:07Z","timestamp":1777581307226,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Comparing the effect of adiponectin versus bevacizumab in decreasing corneal neovascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was conducted on 30 eyes of 30 New Zealand Albino male rabbits. Corneal neovascularization was induced by a single 7-0 silk suture 2\u2009mm long and 1\u2009mm in front of the limbus for 2\u2009weeks. Rabbits were randomly divided into three groups of adiponectin (20 \u00b5g\/mL), bevacizumab (5\u2009mg\/mL) and artificial tears. The treatments continued up to 14\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At the end of 14\u2009days, the average length of vessels in rabbits treated with adiponectin, bevacizumab and control groups decreased from 2.12\u2009\u00b1\u20090.32\u2009mm to 0.89\u2009\u00b1\u20090.46\u2009mm (57.68%\u2009\u00b1\u200919.98%) (P\u2009&lt;\u20090.001), 2.30\u2009\u00b1\u20090.41\u2009mm to 1.30\u2009\u00b1\u20090.58\u2009mm (42.49%\u2009\u00b1\u200927.17%) (P\u2009=\u20090.048) and from 2.12\u2009\u00b1\u20090.44\u2009mm to 1.81\u2009\u00b1\u20090.42\u2009mm (14.81%\u2009\u00b1\u20095.64%) (P\u2009=\u20090.112), respectively. The length of vessels decreased 57.68%\u2009\u00b1\u200919.98% and 42.49%\u2009\u00b1\u200927.17% in adiponectin versus bevacizumab groups, respectively (P\u2009=\u20090.527). The average surface area of vessels in rabbits treated with adiponectin, bevacizumab and control groups reduced from 5.02\u2009\u00b1\u20091.50\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      to 1.40\u2009\u00b1\u20090.75\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      (70.64%\u2009\u00b1\u200917.76%) (P\u2009&lt;\u20090.001) 0.34\u2009\u00b1\u20091.1\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      to 2.80\u2009\u00b1\u20091.04\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      (48.24%\u2009\u00b1\u200919.23%) (P\u2009=\u20090.039) and 5.12\u2009\u00b1\u20092.92\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      to 4.4\u2009\u00b1\u20092.55\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      (14.68%\u2009\u00b1\u20094.19%) (P\u2009=\u20090.117). Mean surface area of vascularization decreased 70.64% \u00b1\u200917.76% and 48.24%\u2009\u00b1\u200919.23% in adiponectin versus bevacizumab, respectively (P\u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of this study suggest that topical adiponectin can decrease recent corneal neovascularization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119874947","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T02:44:05Z","timestamp":1568601845000},"page":"78-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Regression of corneal neovascularization: Adiponectin versus bevacizumab eye drops"],"prefix":"10.1177","volume":"31","author":[{"given":"Alireza","family":"Baradaran-Rafii","sequence":"first","affiliation":[{"name":"Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-6365","authenticated-orcid":false,"given":"Azin","family":"Ashnagar","sequence":"additional","affiliation":[{"name":"Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Heidari Keshel","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayena","family":"Jabbehdari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazaleh","family":"Baradaran-Rafii","sequence":"additional","affiliation":[{"name":"School of Civil Engineering, College of Engineering, University of Tehran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,15]]},"reference":[{"key":"bibr1-1120672119874947","first-page":"274","volume":"38","author":"Benelli U","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr2-1120672119874947","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e31829ceefa"},{"key":"bibr3-1120672119874947","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199811000-00008"},{"key":"bibr4-1120672119874947","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10408"},{"key":"bibr5-1120672119874947","first-page":"7","volume":"2","author":"Baradaran-Rafii A","year":"2007","journal-title":"Iran J 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