{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:23Z","timestamp":1777581323488,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To report the results of intravitreal ranibizumab injection as primary therapy in aggressive posterior retinopathy of prematurity, the process of the disease, and the additive treatments performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective case review included 15 eyes of 8 premature babies with aggressive posterior retinopathy of prematurity who were initially treated with intravitreal ranibizumab injection. The documented data were gestational age, birth weight, gender, postmenstrual age at intravitreal ranibizumab injection, zone of retinopathy of prematurity, reactivation time of disease, iris neovascularization, retinal hemorrhage, anatomical outcome, and additional treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Median gestational age at birth was 26 (range, 23\u201327)\u2009weeks, birth weight was 730 (range, 550\u2013970)\u2009g, and postconceptional age at aggressive posterior retinopathy of prematurity diagnosis and intravitreal ranibizumab injection was 35 (range, 33\u201335)\u2009weeks. Intravitreal ranibizumab injection was performed as primary treatment. Two eyes necessitated a second intravitreal ranibizumab injection. The reactivation of retinopathy of prematurity was 5 (range, 3\u20137)\u2009weeks after intravitreal ranibizumab injection. Recurrence of the disease in Zone II was treated with laser photocoagulation. A favorable outcome was obtained in all eyes (100%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Aggressive posterior retinopathy of prematurity is a serious, rapidly progressing form of retinopathy of prematurity that requires quick and proper management. This study indicates that primary treatment with ranibizumab and laser photocoagulation on recurrence provide favorable anatomical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119886989","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T04:30:46Z","timestamp":1573619446000},"page":"179-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Favorable outcomes in the treatment of aggressive posterior retinopathy of prematurity"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-103X","authenticated-orcid":false,"given":"Nedime","family":"Sahinoglu-Keskek","sequence":"first","affiliation":[{"name":"Adana Research and Training Center, Department of Ophthalmology, Faculty of Medicine, Baskent University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imren","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgin","family":"Torer","sequence":"additional","affiliation":[{"name":"Adana Research and Training Center, Department of Neonatology, Faculty of Medicine, Baskent University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"bibr1-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.12.004"},{"key":"bibr2-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"bibr3-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.01.038"},{"key":"bibr4-1120672119886989","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archopht.1988.01060130517027","volume":"106","author":"Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results","year":"1988","journal-title":"Arch Ophthalmol"},{"key":"bibr5-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00540-1"},{"key":"bibr6-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.07.012"},{"key":"bibr7-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000244291.09499.88"},{"key":"bibr8-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"bibr9-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"bibr10-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001209"},{"key":"bibr11-1120672119886989","doi-asserted-by":"publisher","DOI":"10.7150\/thno\/v01p0395"},{"key":"bibr12-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00840.x"},{"key":"bibr13-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.07.005"},{"key":"bibr14-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.012"},{"key":"bibr15-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.017"},{"key":"bibr16-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.05.009"},{"key":"bibr17-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.4838"},{"key":"bibr18-1120672119886989","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.07.15"},{"key":"bibr19-1120672119886989","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/808639"},{"key":"bibr20-1120672119886989","first-page":"2027","volume":"9","author":"Ar\u00e1mbulo O","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"bibr21-1120672119886989","unstructured":"ClinicalTrials.gov. RAINBOW Study: ranibizumab compared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity, https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT02375971 (accessed 22 October 2018)."},{"key":"bibr22-1120672119886989","unstructured":"Novartis Press Release. Novartis to file for new Lucentis\u00ae (ranibizumab) indication in Retinopathy of Prematurity (ROP), a rare disease in premature infants that often leads to blindness, 22 September 2018, https:\/\/www.novartis.com\/news\/media-releases\/novartis-file-new-lucentis-ranibizumab-indication-retinopathy-prematurity-rop-rare-disease-premature-infants-often-leads-blindness (accessed 22 October 2018)."}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119886989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119886989","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119886989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:00Z","timestamp":1777405500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119886989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/1120672119886989"],"URL":"https:\/\/doi.org\/10.1177\/1120672119886989","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]}}}