{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:56:33Z","timestamp":1793746593884,"version":"4.6.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to test the antiviral effectivity of potassium peroxymonosulfate (RUBYSTA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , KYORIN) against five epidemic keratoconjunctivitis-related types of Human adenovirus D in vitro.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Five types of Human adenovirus D (8, 37, 53, 54 and 56) were incubated with 1% potassium peroxymonosulfate, 0.1% sodium hypochlorite (NaClO) or alcohol-based disinfectant for 30\u2009s or 1\u2009min. These solutions were subjected to measurements of viral titres by infection assays in A549 cells. At day 6 post-infection, both, supernatants and cells, were collected and the viral genome was assessed by real-time polymerase chain reaction analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Treatments with 1% potassium peroxymonosulfate led to significant reduction in all tested Human adenovirus D types comparable to disinfecting effects by 0.1% NaClO. Overall, potassium peroxymonosulfate demonstrated sufficient inactivation of the major epidemic keratoconjunctivitis-causing Human adenovirus D to be considered for disinfection and prevention purposes in ophthalmological clinics and hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrated that potassium peroxymonosulfate is a promising disinfectant for the prevention of epidemic keratoconjunctivitis nosocomial infections in ophthalmological clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672119891408","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T03:48:01Z","timestamp":1575863281000},"page":"379-384","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate"],"prefix":"10.1177","volume":"31","author":[{"given":"Mei","family":"Hashizume","sequence":"first","affiliation":[{"name":"Division of Signalling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Molecular Medical Biochemistry Unit, Biological Chemistry and Engineering Course, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Signalling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan"},{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan"},{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Kitaichi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan"},{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyo","family":"Yawata","sequence":"additional","affiliation":[{"name":"Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Division of Signalling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Molecular Medical Biochemistry Unit, Biological Chemistry and Engineering Course, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Signalling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Molecular Medical Biochemistry Unit, Biological Chemistry and Engineering Course, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-3757","authenticated-orcid":false,"given":"Akinori","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Division of Signalling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Molecular Medical Biochemistry Unit, Biological Chemistry and Engineering Course, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"bibr1-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100766"},{"key":"bibr2-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.01.004"},{"key":"bibr3-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2000.0850"},{"key":"bibr4-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2018.05.011"},{"key":"bibr5-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32389-8"},{"key":"bibr6-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31389-8"},{"key":"bibr7-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01599-4"},{"key":"bibr8-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.4.2014.1.2"},{"key":"bibr9-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2007.12.012"},{"key":"bibr10-1120672119891408","first-page":"2132","volume":"16","author":"Tabbara KF","year":"2010","journal-title":"Mol Vis"},{"key":"bibr11-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.6.938"},{"key":"bibr12-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1990.tb01052.x"},{"key":"bibr13-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1208642"},{"issue":"5","key":"bibr14-1120672119891408","first-page":"384","volume":"111","author":"Akanuma M","year":"2007","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"bibr15-1120672119891408","doi-asserted-by":"publisher","DOI":"10.4265\/bio.11.147"},{"key":"bibr16-1120672119891408","doi-asserted-by":"publisher","DOI":"10.5326\/0380231"},{"key":"bibr17-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.04.008"},{"key":"bibr18-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02608-14"},{"key":"bibr19-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.r00313-09"},{"key":"bibr20-1120672119891408","doi-asserted-by":"publisher","DOI":"10.4058\/jsei.30.325"},{"key":"bibr21-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1007\/BF01719487"},{"key":"bibr22-1120672119891408","first-page":"203","volume":"46","author":"Hernndez A","year":"2000","journal-title":"J Hosp Infect"},{"issue":"2","key":"bibr23-1120672119891408","first-page":"246","volume":"60","author":"Chan YF","year":"2005","journal-title":"Med J Malaysia"},{"issue":"4","key":"bibr24-1120672119891408","first-page":"776","volume":"41","author":"Roongruangchai K","year":"2010","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"bibr25-1120672119891408","doi-asserted-by":"publisher","DOI":"10.4058\/jsei.30.391"},{"key":"bibr26-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.2.726-732.2005"},{"key":"bibr27-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01835-07"},{"key":"bibr28-1120672119891408","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.178772"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119891408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672119891408","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672119891408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:03Z","timestamp":1777405503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672119891408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1177\/1120672119891408"],"URL":"https:\/\/doi.org\/10.1177\/1120672119891408","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]}}}