{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:23:18Z","timestamp":1788466998142,"version":"build-2803163510"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"VISUfarma SPA","award":["Grant"],"award-info":[{"award-number":["Grant"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"\n Purpose:<\/jats:title>\n A prospective, open-label study in 20 professional swimmers evaluated the efficacy and safety of an ophthalmic solution containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS in releasing eye irritation and restoring ocular surface damages after prolonged exposure to chlorinated water.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Individually, one eye was instilled with the ophthalmic solution and the other used as a comparator. Eye drops were self-administered three times a day for 2\u2009months. Tear film breakup time (primary endpoint), Schirmer I test, beating of eyelashes\/min, tear osmolarity, corneal and conjunctival staining with fluorescein, Ocular Surface Disease Index questionnaire, subject satisfaction, visual acuity (secondary endpoints), and Efron Grading Scale were evaluated at screening\/baseline (V1), week 1 (V2), week 2 (V3), week 4 (V4), and week 8 (V5).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n After 2\u2009months, breakup time test significantly improved in the treated eyes (+1.67\u2009s) compared to control (\u22123.00\u2009s) ( p\u2009=\u20090.0002). Corneal and conjunctival surfaces of treated eyes recovered significantly compared to control eyes when assessed by fluorescein staining ( p\u2009<\u20090.0001), Ocular Surface Disease Index ( p\u2009<\u20090.05), and visual analog scale ( p\u2009=\u20090.0348) scores. Improvements were also observed with Schirmer I test, beating of eyelashes, and tear osmolarity, despite without statistical significance. Efron Grading Scale was consistent with the other tests. The ocular tolerability was excellent.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The adequate combination of crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS, contained in the ophthalmic solution VisuXL\n \u00ae<\/jats:sup>\n , has been shown to protect ocular surface from potential damages originating from prolonged exposure to chlorinated water. VisuXL may represent a compelling treatment in other situations beyond dry eye syndrome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1120672120907311","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T01:51:02Z","timestamp":1581904262000},"page":"430-438","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of eye drops containing crosslinked hyaluronic acid and CoQ10 in restoring ocular health exposed to chlorinated water"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-6605","authenticated-orcid":false,"given":"Costanza","family":"Tredici","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Fasciani","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Villano","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Gambini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. 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