{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:20Z","timestamp":1777581380237,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Mooren\u2019s ulcer is a painful, inflammatory chronic keratitis that affects corneal periphery, progressing centripetally, ultimately ending in perforation. The first line of treatment includes systemic immunomodulators, with surgery being the last option. We present a case of bilateral Boston keratoprosthesis implantation for severe Mooren\u2019s ulcer that responded differently in each eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical case:<\/jats:title>\n                    <jats:p>A 32-year-old male with corneal opacification, anterior staphylomas, vision of hand movement, was started on systemic immunosuppression with cyclosporine. After two failed penetrating keratoplasties in each eye, high intraocular pressure despite diode cyclophotocoagulation, and cystic macular edema, we performed Boston keratoprosthesis type 1 in both eyes. The right eye responded initially well, with a best-corrected visual acuity of 20\/80 and normal intraocular pressure. The left eye presented high intraocular pressure, which required cyclophotocoagulation, ultimately resulting in hypotony. Boston keratoprosthesis was performed but had peripheral corneal necrosis that progressed despite amniotic membrane transplantation and aggressive intensive treatment with medroxyprogesterone, autologous platelet-rich-in-growth-factors eye drops, and oral doxycycline. Thus, replacement of the semi-exposed Boston keratoprosthesis with tectonic penetrating keratoplasty was necessary. However, both eyes developed phthisis bulbi with final visual acuity of perception of light with poor localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mainstay treatment of Mooren\u2019s ulcer is systemic immunomodulation. Surgical treatment must be considered only when risk of perforation, preferably with inflammation under control. Penetrating keratoplasty frequently fails, and Boston keratoprosthesis may be a viable option. However, postoperative complications, especially uncontrolled high intraocular pressure, corneal necrosis, and recurrence of Mooren\u2019s ulcer may jeopardize the outcomes and need to be addressed promptly with intensive topical and systemic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120909768","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T05:26:40Z","timestamp":1583472400000},"page":"NP33-NP38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren\u2019s ulcer"],"prefix":"10.1177","volume":"31","author":[{"given":"Marta","family":"Jerez-Pe\u00f1a","sequence":"first","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, Barcelona, Spain"},{"name":"Instituto Universitario Barraquer, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-7301","authenticated-orcid":false,"given":"Borja","family":"Salvador-Culla","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, Barcelona, Spain"},{"name":"Instituto Universitario Barraquer, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda F","family":"de la Paz","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, Barcelona, Spain"},{"name":"Instituto Universitario Barraquer, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael I","family":"Barraquer","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, Barcelona, Spain"},{"name":"Instituto Universitario Barraquer, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Universitat Internacional de Catalunya, Barcelona, 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