{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:00:48Z","timestamp":1780354848056,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>To investigate choroidal thickness changes related to the clinical activity of inflammatory choroidal neovascularization in punctate inner choroidopathy\/multifocal choroiditis as compared to myopic choroidal neovascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Consecutive inflammatory choroidal neovascularization secondary to punctate inner choroidopathy\/multifocal choroiditis, and myopic choroidal neovascularization were retrospectively reviewed. By means of enhanced-depth imaging optical coherence tomography, choroidal thickness was assessed at the same location before choroidal neovascularization development, at choroidal neovascularization onset (baseline), and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eleven eyes with inflammatory choroidal neovascularization and 11 eyes with myopic choroidal neovascularization were analyzed. Choroidal thickness beneath inflammatory choroidal neovascularization significantly increased at baseline and decreased after therapy (\u201cSponge sign\u201d), reaching preclinical values. In particular, mean choroidal thickness under inflammatory choroidal neovascularization was 145\u2009\u00b1\u200985\u2009\u00b5m at the preclinical stage, increased to 210\u2009\u00b1\u2009103\u2009\u00b5m at baseline (p\u2009=\u20090.006), and decreased to 136\u2009\u00b1\u200987\u2009\u00b5m after treatment (p\u2009=\u20090.017). Conversely, no significant choroidal thickness changes were disclosed in myopic choroidal neovascularization eyes, under any location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Optical coherence tomography\u2013based choroidal thickness evaluation may represent an additional useful tool to monitor inflammatory choroidal neovascularization activity. Moreover, choroidal thickness under choroidal neovascularizations could be used to discriminate the origin of choroidal neovascular membrane, either inflammatory or myopic, in doubtful cases and guide the therapeutic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120917621","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T02:07:08Z","timestamp":1588126028000},"page":"1240-1247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The \u201cSponge sign\u201d: A novel feature of inflammatory choroidal neovascularization"],"prefix":"10.1177","volume":"31","author":[{"given":"Chiara","family":"Giuffr\u00e8","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, 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Raffaele, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sacconi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-0409","authenticated-orcid":false,"given":"Maria Vittoria","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Miere","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris Est Creteil, Creteil, 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