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Dysfunction of Bruch\u2019s membrane in both age-related macular degeneration and other ocular diseases is caused mostly by extracellular matrix degeneration, deposit formation, and angiogenesis. Although these factors are dealt in greater detail with respect to the cells that are degenerated such as the retinal pigment epithelium and the endothelial cells, the pathology involving the Bruch\u2019s membrane is often underrated. Since in most of the macular degenerations early degenerative changes are also observed in the Bruch\u2019s membrane, addressing only the cellular component without the underlying membrane will not yield an ideal clinical benefit. This review aims to discuss the factors and the mechanisms affecting the integrity of the Bruch\u2019s membrane, which would aid in developing an effective therapy for these pathologies.<\/jats:p>","DOI":"10.1177\/1120672120919337","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T02:11:37Z","timestamp":1588126297000},"page":"1195-1206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Bruch\u2019s membrane pathology: A mechanistic perspective"],"prefix":"10.1177","volume":"30","author":[{"given":"Aishwarya","family":"Murali","sequence":"first","affiliation":[{"name":"Radheshyam Kanoi Stem Cell Laboratory, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Chennai, 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