{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:02Z","timestamp":1777581422262,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Laboratoires THEA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to assess the efficacy and safety of corneal scrubbing associated with matrix regenerating agent on corneal wound healing in patients with persistent corneal ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective case study in patients with difficult-to-treat corneal ulcer. Corneal scrubbing was performed with a sterile dry cotton bud to eliminate damaged epithelial cells and corneal deposits, promoting epithelial renewal. Regenerating agent was then administered as one eye drop every 2 days in addition to preservative-free ocular lubricants. A bandage contact lens was applied in case of moderate-to-severe corneal pain. Corneal ulcers were regularly assessed until healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 17 patients with a chronic corneal ulcer of various etiologies for several months on average were enrolled. Corneal scrubbing combined with regenerating agent administration led to a rapid corneal ulcer size reduction from 26.4\u2009\u00b1\u200920.6 mm\n                      <jats:sup>2<\/jats:sup>\n                      after scrubbing (before regenerating agent) to 7.2\u2009\u00b1\u20097.1 mm\n                      <jats:sup>2<\/jats:sup>\n                      at day 5, 3.3\u2009\u00b1\u20096.0 mm\n                      <jats:sup>2<\/jats:sup>\n                      at day 10, and 0.9\u2009\u00b1\u20092.3 mm\n                      <jats:sup>2<\/jats:sup>\n                      at day 18. Complete corneal ulcer healing was observed in 35.2% of patients within 10 days, in 70.4% within 18 days, and in all patients within 25 days. Corneal ulcer relapse was observed in two (11.8%) patients after 6 weeks and 5 months, respectively; both were successfully treated using the same procedure. The regenerating agent was well tolerated in all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, combined corneal scrubbing and matrix regenerating therapy (with or without bandage contact lens) led to a rapid healing and successful resolution of persisting corneal ulcers, including large and deep corneal ulcers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120921379","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T02:18:07Z","timestamp":1588126687000},"page":"959-966","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fast and sustained healing of resistant corneal ulcers using corneal scrubbing and matrix regenerating therapy"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6310-9615","authenticated-orcid":false,"given":"Sihem","family":"Lazreg","sequence":"first","affiliation":[{"name":"Centre d\u2019Ophtalmologie Lazreg, Blida, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Labetoulle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Bic\u00eatre, APHP, South Paris University, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-0342","authenticated-orcid":false,"given":"Didier","family":"Renault","sequence":"additional","affiliation":[{"name":"Laboratoires Th\u00e9a, Clermont-Ferrand, France"},{"name":"Corneal Graft Biology, Engineering and Imaging Laboratory, EA2521, Federative Institute of Research in Sciences and Health Engineering, Faculty of Medicine, Jean Monnet University, Saint-Etienne, 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