{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:18Z","timestamp":1791567618764,"version":"4.3.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the short-term changes in corneal endothelial cells after trabeculectomy or XEN Gel Stent implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, interventional, comparative study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Changes in corneal endothelium in patients that underwent XEN Gel Stent implantation or trabeculectomy were prospectively evaluated. Eighty eyes of 62 diagnosed with open-angle glaucoma were divided into two the trabeculectomy and XEN Gel Stent groups. Corneal specular microscopy was performed at the central cornea using a noncontact specular microscope preoperatively and 3 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline mean corneal endothelial cell density in the trabeculectomy group was 2390.3\u2009\u00b1\u2009324.8 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      , and this was significantly reduced to 2148\u2009\u00b1\u2009352.5 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      3 months after surgery, representing a cell loss of 10.0% (p\u2009&lt;\u20090.001). The baseline mean corneal endothelial cell density in the XEN Gel Stent group was 2156.2\u2009\u00b1559.7 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      , and this was significantly reduced to 2098.4\u2009\u00b1\u2009556.2 cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      3 months after surgery, representing a cell loss of 2.1% (p\u2009=\u20090.002). The corneal endothelial cell density change rate of the trabeculectomy group (\u221210.0%\u2009\u00b1\u20099.7%) was statistically higher than the XEN Gel Stent group (\u22122.1%\u2009\u00b1\u200913.8%) (p\u2009=\u20090.002). A statistically significant difference was observed in the trabeculectomy group between the baseline and postoperative values in the coefficient of variation (p\u2009=\u20090.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Trabeculectomy caused more endothelial cell damage than XEN Gel Stent implantation in the short-term follow-up period. The XEN Gel Stent may be the treatment of choice in patients with a significantly low preoperative corneal endothelial cell density.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120924339","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T03:13:59Z","timestamp":1590462839000},"page":"346-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["XEN Gel Stent versus trabeculectomy: Short-term effects on corneal endothelial cells"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-0997","authenticated-orcid":false,"given":"Ali","family":"Olgun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-177X","authenticated-orcid":false,"given":"Eyup","family":"Duzgun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-4465","authenticated-orcid":false,"given":"Aysegul Mavi","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Retina Eye Hospital, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Istinye University SH MYO, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Atakhan","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Medicine Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-1026","authenticated-orcid":false,"given":"S Yekta","family":"Sendul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"bibr1-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834ff1e7"},{"issue":"2","key":"bibr2-1120672120924339","first-page":"90","volume":"71","author":"Dupont G","year":"2016","journal-title":"Rev Med Liege"},{"key":"bibr3-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000803"},{"key":"bibr4-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.01.032"},{"key":"bibr5-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.004"},{"key":"bibr6-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.07.023"},{"key":"bibr7-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000858"},{"key":"bibr8-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13463"},{"key":"bibr9-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3899-7"},{"key":"bibr10-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00462-9"},{"key":"bibr11-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199705000-00010"},{"key":"bibr12-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19453"},{"key":"bibr13-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.016"},{"key":"bibr14-1120672120924339","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20110812-04"},{"key":"bibr15-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.08.022"},{"key":"bibr16-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.024"},{"key":"bibr17-1120672120924339","first-page":"131","volume":"20","author":"Hau S","year":"2009","journal-title":"Curropinophthalmol"},{"key":"bibr18-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000171"},{"key":"bibr19-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73530-5"},{"key":"bibr20-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00080-X"},{"key":"bibr21-1120672120924339","doi-asserted-by":"publisher","DOI":"10.3109\/02713688709034885"},{"key":"bibr22-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100050044028"},{"key":"bibr23-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-009-0740-1"},{"key":"bibr24-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181659e56"},{"key":"bibr25-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3180391a04"},{"key":"bibr26-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1998.760115.x"},{"key":"bibr27-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30405-3"},{"key":"bibr28-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01216-0"},{"key":"bibr29-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3889-1"},{"key":"bibr30-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000301"},{"key":"bibr31-1120672120924339","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13087"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120924339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672120924339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120924339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:36Z","timestamp":1777405536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672120924339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,26]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1177\/1120672120924339"],"URL":"https:\/\/doi.org\/10.1177\/1120672120924339","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,26]]}}}