{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:28Z","timestamp":1777581448722,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this study was to assess visual function by visually evoked potentials in adults with orbital and other primary brain tumors affecting the optic pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective case\u2013control series, patients with orbital (intraconal and extraconal) or midline\/chiasmatic tumors were included. Visually evoked potentials using pattern-reversal visually evoked potential and flash visually evoked potential stimuli were performed according to the international standards. Outcome measures were visually evoked potential parameters of amplitude (\u00b5V) and peak times (ms) measured both for the P100 component (pattern-reversal visually evoked potentials) and the N2P2 complex (flash visually evoked potential). Individual results were also compared with gender-based normative values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A group of 21 adult patients (17 females) and age- and sex-matched controls were evaluated. Tumor location was intraconal (6 meningiomas, 3 hemangiomas, 1 glioma), extraconal (6 meningiomas), and midline (3 pituitary adenomas, 2 hypothalamic\/chiasmatic low-grade gliomas). Abnormal fundus (76%), abnormal pupillary reflexes (71%), reduced visual acuity (62%), strabismus (48%), and proptosis (38%) were present. Visually evoked potential abnormalities were found in at least one eye of all cases. Affected eyes had significantly reduced amplitudes and prolonged peak times for pattern-reversal visually evoked potentials ( p\u2009&lt;\u2009.001) and significantly reduced amplitudes for flash visually evoked potential ( p\u2009&lt;\u2009.001). In unilateral orbital tumors, abnormally prolonged pattern-reversal visually evoked potential peak times were also detected in some contralateral eyes ( n\u2009=\u20096\/16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Visually evoked potential abnormalities were found in all adult patients with orbital and other intracranial primary tumors, even in eyes with normal exam and good visual acuity. Visually evoked potential can be used as a non-invasive ancillary test to characterize and monitor visual function in subjects with these neoplastic lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120925643","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T07:55:05Z","timestamp":1590738905000},"page":"1351-1360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Visual function assessed by visually evoked potentials in adults with orbital and other primary intracranial tumors"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-4801","authenticated-orcid":false,"given":"Patr\u00edcia de Freitas","family":"Dotto","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Berezovsky","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Yuri","family":"Sacai","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Martins","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Gustavo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange Rios","family":"Salom\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Eletrofisiologia Visual Cl\u00ednica, Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"bibr1-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0177-5"},{"key":"bibr2-1120672120925643","doi-asserted-by":"publisher","DOI":"10.4314\/gmj.v49i3.9"},{"key":"bibr3-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2019.1658790"},{"key":"bibr4-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou283"},{"key":"bibr5-1120672120925643","first-page":"270","volume":"19","author":"Miranda-Filho A","year":"2017","journal-title":"Neuro Oncol"},{"key":"bibr6-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.07.003"},{"key":"bibr7-1120672120925643","unstructured":"Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975-2016. Bethesda, MD: National Cancer Institute, 2019. https:\/\/seer.cancer.gov\/csr\/1975_2016\/ (accessed 3 February 2020)."},{"key":"bibr8-1120672120925643","unstructured":"Minist\u00e9rio da Sa\u00fade, Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva. Estimativa 2018\u2014Incid\u00eancia de c\u00e2ncer no Brasil. Rio de Janeiro, Brazil: INCA, 2018. http:\/\/www1.inca.gov.br\/rbc\/n_64\/v01\/pdf\/15-resenha-estimativa-2018-incidencia-de-cancer-no-brasil.pdf (accessed 3 February 2020)."},{"key":"bibr9-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1626192"},{"key":"bibr10-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12328-8"},{"key":"bibr11-1120672120925643","first-page":"211","volume":"93","author":"Perkins A","year":"2016","journal-title":"Am Fam Physician"},{"key":"bibr12-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30990-5"},{"key":"bibr13-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000257"},{"key":"bibr14-1120672120925643","first-page":"800","volume":"8","author":"Sefi-Yurdakul N","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"bibr15-1120672120925643","doi-asserted-by":"publisher","DOI":"10.4103\/tjosr.tjosr_49_18"},{"key":"bibr16-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(94)90173-2"},{"key":"bibr17-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30309-8"},{"key":"bibr18-1120672120925643","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2001.10.5.2"},{"key":"bibr19-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-016-9553-y"},{"key":"bibr20-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-017-9594-x"},{"key":"bibr21-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510060064010"},{"key":"bibr22-1120672120925643","doi-asserted-by":"publisher","DOI":"10.3109\/01676838309019177"},{"key":"bibr23-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.1.31"},{"key":"bibr24-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/BF00155032"},{"key":"bibr25-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(92)90002-S"},{"key":"bibr26-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-014-9448-8"},{"key":"bibr27-1120672120925643","first-page":"654","volume":"130","author":"Gutzwiller EM","year":"2018","journal-title":"J Neurosurg"},{"key":"bibr28-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-018-9635-0"},{"key":"bibr29-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-018-9659-5"},{"key":"bibr30-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-006-9025-x"},{"key":"bibr31-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-019-00969-5"},{"key":"bibr32-1120672120925643","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.oa.2014-0023"},{"key":"bibr33-1120672120925643","first-page":"3600","volume":"60","author":"Salom\u00e3o SR","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr34-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"bibr35-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0981"},{"key":"bibr36-1120672120925643","first-page":"1173","volume":"34","author":"Pojda-Wilczek D","year":"2002","journal-title":"Neurol Neurochir Pol"},{"key":"bibr37-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)80057-8"},{"key":"bibr38-1120672120925643","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.922195"},{"key":"bibr39-1120672120925643","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.169462"},{"key":"bibr40-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.06.034"},{"key":"bibr41-1120672120925643","first-page":"273","volume":"6","author":"Ghassibi MP","year":"2017","journal-title":"Asia Pac J Ophthalmol"},{"key":"bibr42-1120672120925643","doi-asserted-by":"publisher","DOI":"10.1080\/09286580590932752"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120925643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672120925643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120925643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:39Z","timestamp":1777405539000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672120925643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/1120672120925643"],"URL":"https:\/\/doi.org\/10.1177\/1120672120925643","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]}}}