{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:56Z","timestamp":1777581476268,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006010","name":"Bayer Schering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect and the safety of intravitreal aflibercept in patients affected by choroidal neovascularization secondary to angioid streaks with a long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre, open-label, phase IIb study (EYLEA-STRIE, EudraCT Number 2014-000986-30) involving four Italian centres (IRCCS Ospedale San Raffaele (Milano), Fondazione G.B. Bietti (Roma), Policlinico (Milano), Ospedale Luigi Sacco (Milano)). Patients with active choroidal neovascularization secondary to angioid streaks with foveal involvement were prospectively enrolled and followed for 18\u00a0months. All the patients received intravitreal 2\u00a0mg\/0.05\u2009mL aflibercept at the time of enrolment, followed by a pro-re-nata regimen for 48\u00a0weeks. Best-corrected visual acuity and central macular thickness were measured monthly. Adverse events were monitored at each visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three eyes of 20 patients were analysed. Mean number of injections per patient was 4.30\u2009\u00b1\u20091.2. At week 48, the best-corrected visual acuity was 0.42\u2009\u00b1\u20090.40 LogMAR (p\u2009=\u20090.6 from baseline) and 18 eyes (81.8%) featured stability within 15 letters. The central macular thickness significantly reduced (p\u2009=\u20090.03). Eleven ocular non-serious adverse events and two serious adverse events were observed (one case of endophthalmitis and one case of acute gastritis were reported).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intravitreal aflibercept represents a valid option for the management of choroidal neovascularization complicating angioid streaks. Further studies with longer follow-up and different therapeutic regimens are warranted to ascertain the best control of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120928305","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T05:34:06Z","timestamp":1591076046000},"page":"1146-1153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Intravitreal aflibercept for management of choroidal neovascularization secondary to angioid streaks"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-7961","authenticated-orcid":false,"given":"Maurizio Battaglia","family":"Parodi","sequence":"first","affiliation":[{"name":"San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-0409","authenticated-orcid":false,"given":"Maria Vittoria","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Marchese","sequence":"additional","affiliation":[{"name":"Universita Vita-Salute San Raffaele, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"San Raffaele Hospital, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-913X","authenticated-orcid":false,"given":"Francesco","family":"Viola","sequence":"additional","affiliation":[{"name":"University of Milan, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[{"name":"Eye Clinic Ospedale Sacco Universita degli Studi Di Milano, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-1563","authenticated-orcid":false,"given":"Monica","family":"Varano","sequence":"additional","affiliation":[{"name":"Fondazione G.B. 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