{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:39:19Z","timestamp":1777581559914,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2314-B-303-011-MY3"],"award-info":[{"award-number":["MOST 106-2314-B-303-011-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD-TPE-108-47"],"award-info":[{"award-number":["TCRD-TPE-108-47"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD-TPE-108-8"],"award-info":[{"award-number":["TCRD-TPE-108-8"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of 1% topical bevacizumab (10\u2009mg\/mL) on newly formed corneal neovascularization (NV) after penetrating keratoplasty (PK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a retrospective case series reporting three eyes (three patients) of with newly formed corneal NV after corneal transplantation. All eyes had pre-existing corneal NVs and were high risk corneal graft rejection cases. One percent topical bevacizumab was started immediately after corneal NV formation post-PK. Topical bevacizumab was kept at twice weekly throughout the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Regression of corneal NV without donor graft invasion was noted in all three patients (100%). Duration of topical bevacizumab use was 13 to 36\u2009months. All three corneal grafts (100%) remained clear and no signs of graft rejection were noted for the period of observation. There were no associated systemic or ocular adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Long-term use of topical 1% bevacizumab may be a safe and efficient treatment for corneal NVs and prevention of graft rejections after corneal transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120939504","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T07:57:32Z","timestamp":1593676652000},"page":"NP48-NP52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term topical bevacizumab for prevention of corneal graft rejections"],"prefix":"10.1177","volume":"31","author":[{"given":"Hua-Hsuan","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-1647","authenticated-orcid":false,"given":"Elizabeth P","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei"},{"name":"School of Medicine, Tzu Chi University, Hua-Liang"},{"name":"Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"bibr1-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.039"},{"key":"bibr2-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2012.01.005"},{"key":"bibr3-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.132"},{"key":"bibr4-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4571"},{"key":"bibr5-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.18"},{"key":"bibr6-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3745"},{"key":"bibr7-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2851-8"},{"key":"bibr8-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.003"},{"key":"bibr9-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01049.x"},{"key":"bibr10-1120672120939504","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.013"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120939504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672120939504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120939504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:55Z","timestamp":1777405555000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672120939504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/1120672120939504"],"URL":"https:\/\/doi.org\/10.1177\/1120672120939504","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]}}}