{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:28:51Z","timestamp":1782185331969,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004491","name":"balikesir \u00fcniversitesi","doi-asserted-by":"publisher","award":["Project no: BAP. 2018\/159"],"award-info":[{"award-number":["Project no: BAP. 2018\/159"]}],"id":[{"id":"10.13039\/501100004491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Pterygium is a common lesion of the ocular surface, and its etiology and pathogenesis are still uncertain. This study aimed to investigate the role of apoptosis and proliferation in pterygium formation and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>In this study, p53, Bcl-2, and Ki-67 expression levels were evaluated in primary pterygium ( n\u2009=\u200935) and recurrent pterygium ( n\u2009=\u200932) tissue samples and compared with normal conjunctiva ( n\u2009=\u200930) tissue samples. In addition, recurrent pterygiums were divided into three groups based on recurrence time, and their p53, Bcl-2, and Ki-67 expression levels were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results show that p53, Bcl-2, and Ki-67 expression levels were significantly higher in the pterygium tissue samples as compared to the control group ( p\u2009&lt;\u20090.001, p\u2009&lt;\u20090.001, and p\u2009&lt;\u20090.001, respectively). When primary and recurrent pterygium tissues were compared, bcl-2 expression was higher in recurrent pterygium tissue samples ( p\u2009=\u20090.003). However, when Ki-67 and p53 expression levels were evaluated, no significant difference was found between primary and recurrent pterygium ( p\u2009=\u20090.215, p\u2009=\u20090.321, respectively). Also, p53 and Ki-67 expression were correlated in pterygium tissue samples, and Bcl-2 expression was significantly higher in pterygium that recurrence in the first 6\u2009months after surgery. There was no difference between groups 1, 2, and 3 in terms of p53 and Ki-67 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Antiapoptotic mechanisms and proliferation play an important role in the etiopathogenesis of pterygium. Furthermore, Bcl-2 expression may be important in pterygium recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120945903","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T04:15:26Z","timestamp":1595564126000},"page":"1232-1237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Bcl-2, p53, and Ki-67 expression in pterygium and normal conjunctiva and their relationship with pterygium recurrence"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-9025","authenticated-orcid":false,"given":"Meydan","family":"Turan","sequence":"first","affiliation":[{"name":"Ophthalmology Clinic, Balikesir Ataturk City Hospital, Balikesir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulay","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, 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