{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:10:23Z","timestamp":1790835023961,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the morphological and functional outcome of oral eplerenone for treatment of patients with chronic central serous chorioretinopathy (CSC) in a real life experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>In this retrospective study, we reviewed the clinical files of 30 patients with chronic CSC. All patients were treated with eplerenone for a period of 6\u2009weeks or 3\u2009months depending on the clinical response. Main outcome measures included: best corrected visual acuity (BCVA), central macular thickness (CMT) and height of the subretinal fluid (SRF). Comparisons between responders and non-responders were performed to identify factors that were predictive of the treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All patients were treated with eplerenone 18 \u00b1 20\u2009weeks after onset of the first symptoms. BCVA (LogMAR) improved from 0.2 \u00b1 0.2 to 0.13 \u00b1 0.18 at 6\u2009weeks ( p = 0.01) and to 0.09 \u00b1 0.15 at 3\u2009months ( p = 0.01). Mean CMT decreased from 409 \u00b1 136 to 323 \u00b1 87\u2009\u00b5m at 6\u2009weeks ( p = 0.001) and to 298 \u00b1 98\u2009\u00b5m at 3\u2009months ( p = 0.01). Mean height of SRF decreased from 153 \u00b1 126 to 73 \u00b1 79\u2009\u00b5m at 6\u2009weeks ( p = 0.001) and to 49 \u00b1 88\u2009\u00b5m at 3\u2009months ( p = 0.005). Complete resolution of SRF was achieved in 20 patients after 3\u2009months (67%). Reported stress in the medical history was the only statistical significant predictive factor associated with a positive treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study showed a statistically significant improvement of the best corrected visual acuity and a significant reduction of macular thickness and subretinal fluid in patients with chronic CSC treated with oral eplerenone, especially in patients under stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120952648","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T01:53:15Z","timestamp":1598579595000},"page":"1885-1891","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Eplerenone for treatment of chronic central serous 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