{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:46:00Z","timestamp":1787618760106,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Peripapillary pachychoroid syndrome is a new variant of pachychoroid disease recently described. It is important to establish the features and pathogenic mechanisms of this novel entity and its possible association with type 1 neovascularization. The aim of this study is to report a case of peripapillary pachychoroid neovasculopathy, a novel entity of pachychoroid spectrum disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 51-year-old woman was referred to our macula service due to macular pigmentary changes in her right eye. On examination, best corrected visual acuity was 20\/20 Snellen equivalent in both eyes. Funduscopy revealed pigmentary changes in the papillonasal bundle in her right eye with mottled autofluorescence in the same area where pigmentary changes. Spectral-domain optical coherence tomography illustrated a shallow irregular pigment epithelium detachment (PED) which appears as \u201cdouble layer sign\u201d overlying pachyvessels, with hyper-flow signal beneath it and a large network of neovascularization revealed by cross-sectional optical coherence tomography angiography. Indocyanine green angiography confirmed the pachyvessels and choroidal hyper-permeability in the peripapillary region. A diagnosis of peripapillary pachychoroid neovasculopathy was made and good visual and anatomical outcomes were achieved with a treat-and-extend regimen with intravitreal aflibercept.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We report a novel entity within the pachychoroid spectrum disease, the peripapillary pachychoroid neovasculopathy, which could improve our understanding of the pathogenic mechanism of choroidal neovascularization in pachychoroid disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120953071","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:14:55Z","timestamp":1598408095000},"page":"NP149-NP153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Peripapillary pachychoroid neovasculopathy: A novel entity"],"prefix":"10.1177","volume":"32","author":[{"given":"Javier","family":"Montero Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-0462","authenticated-orcid":false,"given":"Lidia","family":"Remol\u00ed Sargues","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-0903","authenticated-orcid":false,"given":"Clara","family":"Monferrer Adsuara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Castro Navarro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Navarro Palop","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Cervera Taulet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"bibr1-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0158-4"},{"key":"bibr2-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000331"},{"key":"bibr3-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000742"},{"key":"bibr4-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001907"},{"key":"bibr5-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19315"},{"key":"bibr6-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.08.028"},{"key":"bibr7-1120672120953071","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.06.033"},{"key":"bibr8-1120672120953071","volume":"2018","author":"Anzidei R","year":"2018","journal-title":"Case 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