{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T22:53:49Z","timestamp":1785106429270,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib\/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib\/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.<\/jats:p>","DOI":"10.1177\/1120672120962044","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T03:13:43Z","timestamp":1601522023000},"page":"NP109-NP113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib\/trametinib therapy for advanced melanoma"],"prefix":"10.1177","volume":"32","author":[{"given":"Maria","family":"Brambati","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-7261","authenticated-orcid":false,"given":"Alessandro","family":"Marchese","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-9682","authenticated-orcid":false,"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Maria","family":"Modorati","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-6712","authenticated-orcid":false,"given":"Elisabetta","family":"Miserocchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"bibr1-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"bibr2-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000505"},{"key":"bibr3-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.12.003"},{"issue":"4","key":"bibr4-1120672120962044","first-page":"628","volume":"26","author":"Lim J","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"key":"bibr5-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002451"},{"key":"bibr6-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.038"},{"key":"bibr7-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.07.003"},{"key":"bibr8-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640150075022"},{"key":"bibr9-1120672120962044","volume":"37","author":"Stein ZL.","year":"1980","journal-title":"Am J Hosp Pharm"},{"key":"bibr10-1120672120962044","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0787-5"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120962044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672120962044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672120962044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:43:30Z","timestamp":1777405410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672120962044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/1120672120962044"],"URL":"https:\/\/doi.org\/10.1177\/1120672120962044","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}