{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:48:14Z","timestamp":1788482894735,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of this study is to test non-inferiority of a lower dose of crosslinked hyaluronic acid (CLHA) to a higher dose of carmellose eye drop in menopause patients receiving antidepressant treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective, double-blind, single-center study enrolled sixty female patients. Mean age was 63.25\u2009\u00b1\u20099.13\u2009years. We examined patients with Schirmer I, breakup time (TBUT) and the ocular surface disease index (OSDI) at the first visit. Tear A eyedrops were formulated with crosslinked hyaluronic acid, coenzyme Q10 and vitamin E. Control tear B was formulated with carmellose sodium. Posology was two and five times, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After 2\u2009months of treatment, the tear A obtained 14.12\u2009\u00b1\u20097.47 score points for OSDI ( t\u2009=\u200911.74, p\u2009&lt;\u20090.01), and tear B obtained 19.46\u2009\u00b1\u200910.03 score points ( t\u2009=\u20097.59, p\u2009&lt;\u20090.01). The tear A obtained 13.77\u2009\u00b1\u20097.78 score points for Schirmer test ( t\u2009=\u20090.88, p\u2009&gt;\u20090.05), and tear B obtained 14.20\u2009\u00b1\u20098.62 score points ( t\u2009=\u20092.92, p\u2009&lt;\u20090.01). The tear A obtained 8.30\u2009\u00b1\u20092.08\u2009s for TBUT ( t\u2009=\u200915.50, p\u2009&lt;\u20090.01), and tear B obtained 7.23\u2009\u00b1\u20092.40\u2009s ( t\u2009=\u20098.79, p\u2009&lt;\u20090.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lower total daily dose of crosslinked hyaluronic acid eyedrops obtained similar efficacy results in terms of tear stability and subjective dry eye sensation than higher carmellose total daily dose. A lower total daily dose of crosslinked eyedrops was sufficient to achieve better dry eye disease management compared to carmellose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120972026","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T21:02:38Z","timestamp":1604696558000},"page":"658-663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants"],"prefix":"10.1177","volume":"32","author":[{"given":"Jos\u00e9-Manuel","family":"Serrano-Morales","sequence":"first","affiliation":[{"name":"Department of Physics of Condensed Matter, Optics Area, University of Seville, Seville, Andalucia, 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