{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:56:36Z","timestamp":1784865396383,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess long-term vascular density measured by optical coherence tomography angiography (OCT-A) in former preterm children with history of retinopathy of prematurity (ROP) with and without need of laser treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This observational study included former preterm children that developed ROP stage 2 or 3. Infants were divided in two groups according to previous need of laser treatment, and underwent a complete ophthalmologic evaluation, including assessment of macular morphologic and vascular parameters by OCT-A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen eyes were included in group 1 (laser-requiring ROP) and 19 in group 2 (non-treated ROP). Group 1 had lower mean gestational age and birth weight values than group 2 ( p\u2009&lt;\u20090.001 and p\u2009&lt;\u20090.001, respectively). Best corrected visual acuity (BCVA) was lower in group 1 (0.08\u2009\u00b1\u20090.04 logMAR vs 0.04\u2009\u00b1\u20090.07 logMAR, p\u2009=\u20090.03). Laser-requiring ROP had lower vascular parameters, especially of central and internal vascular density (9.15\u2009\u00b1\u20092.75 vs 10.52\u2009\u00b1\u20090.86\u2009mm\n                      <jats:sup>\u22121<\/jats:sup>\n                      , p\u2009=\u20090.05; 13.74\u2009\u00b1\u20091.00 vs 15.86\u2009\u00b1\u20090.64\u2009mm\n                      <jats:sup>\u22121<\/jats:sup>\n                      , p\u2009=\u20090.05; respectively), and lower avascular zone circularity (0.58\u2009\u00b1\u20090.06 vs 0.76\u2009\u00b1\u20090.02, p\u2009&lt;\u20090.001). Mean macular thickness was higher in group 1 (300.50\u2009\u00b1\u200910.50 vs 281.11\u2009\u00b1\u20092.50\u2009\u03bcm, p\u2009=\u20090.05). Best corrected visual acuity (BCVA) was correlated with superficial vascular density ( p\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Laser-requiring ROP seems to result in a decrease of long-term BCVA, which is at least partially attributed to a decrease in superficial macular vascular density. However, prematurity degree was more pronounced in children that required treatment, which might have influenced our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120983204","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T07:50:51Z","timestamp":1609228251000},"page":"3337-3341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term macular vascular density measured by OCT-A in children with retinopathy of prematurity with and without need of laser treatment"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-2756","authenticated-orcid":false,"given":"Ana Rita","family":"Carreira","sequence":"first","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-1102","authenticated-orcid":false,"given":"Diogo","family":"Lopes","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-7248","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vide-Escada","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Campos","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Hospital Garcia de Orta EPE, Almada, 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