{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:26:26Z","timestamp":1784701586225,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To analyze different clinical and anatomical features in treatment-na\u00efve non-exudative macular neovascularizations (MNVs) secondary to age-related macular disease (AMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective longitudinal study with a minimum follow-up of 1 year, 31 eyes of 28 consecutive AMD patients (mean age 75\u2009\u00b1\u20099\u2009years) with treatment-na\u00efve non-exudative MNV were enrolled. Patients were divided in: short-term activated MNV group (exudation before 6-month) and quiescent MNV group (per definition no exudation during a minimum 6-month follow-up) showing no or late activation during follow-up (persistently quiescent and long-term activated MNV group, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During the follow-up (mean duration: 22\u2009\u00b1\u20099\u2009months) four eyes (13%) showed exudation before 6-month follow-up (short-term activated MNV group), whereas 21 eyes (68%) did not develop signs of exudation (persistently quiescent group), and six eyes (19%) developed exudation after the minimum 6-month follow-up (long-term activated MNV group). Monthly MNV growth rate was significantly higher in the short-term activated MNV group (growth rate of 13.30%\/month), vs persistently quiescent MNV group (0.64%\/month, p\u2009&lt;\u20090.001) and long-term activated quiescent MNV group (1.07%\/month, p\u2009&lt;\u20090.001). Furthermore, at the baseline, perfusion density of short-term activated MNV group was significantly greater in comparison to persistently quiescent MNV group ( p\u2009=\u20090.001) and long-term activated MNV group ( p\u2009=\u20090.106).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We reported two different patterns for subclinical MNVs: subclinical MNVs characterized by short-term activation which could represent simply a pre-exudative stage in the development of an ordinary type 1 MNV, and quiescent MNVs characterized by low rate of growth and possible long-term activation. Analysis of OCT-A features may predict short-term activation for subclinical MNV but no features could predict the long-term activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672120986370","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:46:12Z","timestamp":1610671572000},"page":"3164-3176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Treatment-na\u00efve quiescent macular neovascularization secondary to AMD: The 2019 Young Investigator Lecture of Macula Society"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-9581","authenticated-orcid":false,"given":"Giuseppe","family":"Querques","sequence":"first","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal Creteil University Paris Est, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sacconi","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Capuano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal Creteil University Paris Est, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-6743","authenticated-orcid":false,"given":"Adriano","family":"Carnevali","sequence":"additional","affiliation":[{"name":"Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Department of Ophthalmology, University Hospital \u201cMagna Graecia,\u201d Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Colantuono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal Creteil University Paris Est, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-6177","authenticated-orcid":false,"given":"Marco","family":"Battista","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-8210","authenticated-orcid":false,"given":"Alexandra","family":"Miere","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal Creteil University Paris Est, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-7311","authenticated-orcid":false,"given":"Mariacristina","family":"Parravano","sequence":"additional","affiliation":[{"name":"Foundation G.B. 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