{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:58:55Z","timestamp":1793429935910,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of the iStent inject device combined with phacoemulsification in Asian eyes with primary open angle glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study of combined phacoemulsification and iStent inject surgeries performed in a single institution from July 2017 to August 2019 on patients with co-existing cataracts and primary open angle glaucoma (POAG). Outcome measures included best-corrected visual acuity, intraocular pressure (IOP), number of glaucoma eyedrop medications, and surgical complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 95 eyes were included. Majority of subjects were male (59, 62.1%) and Chinese (83, 87.4%). Mean age was 74.7\u2009\u00b1\u20098.7\u2009years. Pre-operatively, mean IOP was 16.2\u2009\u00b1\u20094.3\u2009mmHg and number of medications was 1.9\u2009\u00b1\u20090.9. Significant post-operative reduction in mean IOP was observed at all timepoints \u2013 post-operative month (POM)1: 3.0\u2009\u00b1\u20095.6\u2009mmHg reduction ( n\u2009=\u200995, p\u2009&lt;\u20090.05); POM3: 1.6\u2009\u00b1\u20093.8\u2009mmHg ( n\u2009=\u200966, p\u2009&lt;\u20090.05); POM6: 1.8\u2009\u00b1\u20094.7\u2009mmHg ( n\u2009=\u200955, p\u2009&lt;\u20090.05); POM12: 1.3\u2009\u00b1\u20094.2\u2009mmHg ( n\u2009=\u200948) ( p\u2009&lt;\u20090.05). The number of glaucoma medications was also reduced from a mean of 1.9\u2009\u00b1\u20090.8 to 0.6\u2009\u00b1\u20091.0 at POM12 ( p\u2009&lt;\u20090.05). Intraoperatively, one case of malignant glaucoma occurred. Post operatively, implant obstruction by iris was observed in two eyes post-operatively requiring iridoplasty. One case of cystoid macular edema and one case of drop in visual acuity due to glaucoma progression was\/were also observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Asian eyes undergoing combined phacoemulsification and iStent inject surgery demonstrate a significant and sustained reduction in both IOP and number of glaucoma medications. Overall, there is a good safety profile for iStent inject.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211000641","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:46:30Z","timestamp":1616373990000},"page":"288-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined phacoemulsification and iStent inject implantation in Asian eyes"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-1019","authenticated-orcid":false,"given":"Jeremy","family":"Hu YW","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Ang CH","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan O\u2019Neill C.","family":"Tecson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore"},{"name":"Cardinal Santos Medical Centre, San Juan, Metro Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kan Tsia-Chuen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-5126","authenticated-orcid":false,"given":"Leonard","family":"Yip WL","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang 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