{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:23:24Z","timestamp":1778279004830,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To describe the use of intracameral recombinant tissue plasminogen activator (r-tPA) in the treatment of severe fibrinous reactions in toxic anterior segment syndrome (TASS) after cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A case series of 59 eyes of 59 patients with severe fibrinous anterior chamber reaction following cataract surgery who received intracameral r-tPA (25\u2009\u00b5g\/0.1\u2009ml). The main outcome measures after intracameral r-tPA were the incidence of complete fibrinolysis, time of maximal effect, visual acuity, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Severe fibrinous reactions appeared 11.5\u2009\u00b1\u20095.3\u2009days after cataract surgery. Fibrinolysis was observed 2.33\u2009\u00b1\u20092.70\u2009days after rtPA use and 36 eyes (61%) exhibited resolution of the fibrin by the end of the first day following injection ( p\u2009&lt;\u20090.001). Transient corneal edema observed at 1-day after injection was the only complication reported during the injection of r-tPA or at follow-up. Eight eyes (13.6%) required a second r-tPA injection. Best-corrected visual acuity improved from 0.88\u2009\u00b1\u20090.67 logMAR units before rtPA injection to 0.48\u2009\u00b1\u20090.49 logMAR units at 1-month ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The application of r-tPA was a quick and efficacious therapeutic approach for the management of severe fibrinous reactions in TASS after cataract surgery. In a clinical setting, intracameral r-tPA may be useful when rapid visual recovery is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211002064","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T13:05:53Z","timestamp":1615813553000},"page":"200-204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Intracameral r-tPA for the management of severe fibrinous reactions in TASS after cataract surgery"],"prefix":"10.1177","volume":"32","author":[{"given":"Perach","family":"Osaadon","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadav","family":"Belfair","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itay","family":"Lavy","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Walter","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-4354","authenticated-orcid":false,"given":"Jaime","family":"Levy","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hadassah Medical Center, Jerusalem, 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