{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:34:45Z","timestamp":1785454485203,"version":"3.56.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019123","name":"Operation Eyesight Universal Institute for Eye Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019123","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005809","name":"hyderabad eye research foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31\u2009years (median, 24\u2009years; range, 2\u201360\u2009years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n\u2009=\u200915, 60%), human immunodeficiency virus infection ( n\u2009=\u20093, 12%), conjunctival xerosis ( n\u2009=\u20091, 4%), and topical steroid use ( n\u2009=\u20091, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n\u2009=\u200936) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n\u2009=\u200949) included excisional biopsy ( n\u2009=\u200931, 62%), topical immunotherapy (IFN \u03b12B) ( n\u2009=\u200911; 22%), topical Mitomycin C (MMC) ( n\u2009=\u20093, 6%), enucleation ( n\u2009=\u20091, 2%), orbital exenteration ( n\u2009=\u20092, 4%), and plaque brachytherapy (PBT) ( n\u2009=\u20091, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41\u2009months (median 30\u2009months; range, 1\u2013164\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211007109","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T05:53:02Z","timestamp":1617601982000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature"],"prefix":"10.1177","volume":"32","author":[{"given":"Vijitha S","family":"Vempuluru","sequence":"first","affiliation":[{"name":"Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monalisha","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 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