{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:24:34Z","timestamp":1788269074612,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Retrospective cohort study evaluating long term keratoconus progression amongst cross-linking (CXL) treated pediatric patients in the treated and the fellow untreated eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data on 60 eyes of 30 patients, 18\u2009years old or younger, who underwent CXL in at least one eye was collected and analyzed. Follow-up measurements taken from the treated and untreated eye up to 7\u2009years after CXL treatment, were compared to baseline measurements. Parameters included uncorrected distance visual acuity (UCDVA), best-corrected spectacle visual acuity (BCSVA), manifest refraction, pachymetry, corneal tomography, and topography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age of patients was 16\u2009\u00b1\u20092.1\u2009years. For the treated eyes, during follow-up period mean UCDVA had improved (from 0.78\u2009\u00b1\u20090.22 at baseline to 0.58\u2009\u00b1\u20090.26\u2009logMAR at 7\u2009years; p\u2009=\u20090.13), as well as mean BCSVA (from 0.23\u2009\u00b1\u20090.107 at baseline to 0.172\u2009\u00b1\u20090.05\u2009logMAR at 7\u2009years; p\u2009=\u20090.37). The mean average keratometry showed a significant flattening (from 49.95\u2009\u00b1\u20094.04 to 47.94\u2009\u00b1\u20093.3 diopters (D); p\u2009&lt;\u20090.001), However there was no change in the mean maximal keratometry. The mean minimal corneal thickness (MCT) showed a significant mild reduction of 26\u2009\u00b5m ( p\u2009=\u20090.006). Although statistically insignificant, the mean manifest cylinder was also reduced to 2D ( p\u2009=\u20090.15). During the follow-up period, eight untreated eyes (26.6%) deteriorated and underwent CXL, while only one treated eye (3.33%) required an additional CXL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CXL is a safe and efficient procedure in halting keratoconus progression in the pediatric population, the fellow eye needs to be carefully monitored but only a 25% of the patients will require CXL in that eye during a period of 7\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211020632","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T13:14:37Z","timestamp":1622639677000},"page":"1482-1490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Seven years follow-up of corneal cross-linking (CXL) in pediatric patients: Evaluation of treated and untreated eye"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-7630","authenticated-orcid":false,"given":"Iliya","family":"Simantov","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-7545","authenticated-orcid":false,"given":"Lior","family":"Or","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-100X","authenticated-orcid":false,"given":"Inbal","family":"Gazit","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-8772","authenticated-orcid":false,"given":"Biana","family":"Dubinsky-Pertzov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zadok","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Pras","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shamir (Assaf Harofeh) Medical Center, Zerifin, 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